急性胰腺炎营养支持治疗研究进展

Research Progresses of Nutritional Support in Acute Pancreatitis

急性胰腺炎(AP)是临床常见的一种急腹症,发病急、进展快,严重危及患者生命,目前救治AP的主要手段以液体复苏、营养支持和镇痛等支持疗法为主。AP常伴随严重的生理紊乱和高分解代谢状态,如糖异生、蛋白质分解和脂肪动员增强,导致机体出现负氮平衡和免疫功能减退,严重影响AP的转归和预后。因此正确选择营养支持治疗方式和时机以及生态免疫营养素的应用,对于降低AP并发症发生率和死亡率有重要保障作用。

Acute pancreatitis(AP)is a common gastrointestinal disorder with the characteristics of acute onset,rapid progress,multiple complications and high mortality.Supportive care has still been the primary treatment for this disease,for the absence of special and effective therapeutic strategies.AP is often accompanied by severe physiological disorders and high catabolism,such as gluconeogenesis,proteolysis and fat mobilization,resulting in negative nitrogen balance and immune dysfunction,which seriously affect the prognosis and prognosis of AP.Therefore,timely,reasonable and effective nutrition support is of great significance in reducing the incidence of relevant complications and mortality.The current review focuses on the types,timing and ecological immune nutrients of nutrition support in AP.