阿托伐他汀联合缬沙坦对慢性肾炎的疗效及对患者血清hs-CRP、TNF-α和BUN的影响

Effect of Atorvastatin Combined with Valsartan on Chronic Nephritis and the Effect on Serum hs-CRP,TNF-α and BUN in Patients

目的:探讨阿托伐他汀联合缬沙坦治疗慢性肾炎的效果及对患者血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)和尿素氮(BUN)的影响。方法:选取2015年9月-2017年6月于本院就诊的慢性肾炎患者84例。按照随机数字表法将其分为观察组和对照组,每组各42例。对照组单用缬沙坦治疗,观察组联合阿托伐他汀,两组均治疗3个月。比较两组治疗前后的血脂、肾功能及炎症指标,比较两组临床疗效。结果:治疗后,观察组低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)均低于治疗前和对照组,比较差异均有统计学意义(P<0.05);治疗后,两组24 h尿蛋白量、BUN、hs-CRP、TNF-α均低于治疗前,且观察组均低于对照组,比较差异均有统计学意义(P<0.05);观察组总有效率92.86%(39/42),高于对照组的76.19%(32/42),比较差异有统计学意义(χ~2=4.459,P=0.035)。结论:阿托伐他汀联合缬沙坦治疗慢性肾炎效果显著,可更好地调节血脂,改善肾功能,减轻炎症反应,值得推广。

Objective:To investigate the effect of Atorvastatin combined with Valsartan on chronic glomerulonephritis and its effects on serum high-sensitivity C reactive protein(hs-CRP),tumor necrosis factorα(TNF-α)and blood urea nitrogen(BUN).Method:A total of 84 patients with chronic nephritis in our hospital from September 2015 to June 2017 were selected.According to the random number table method,they were divided into observation group and control group,42 cases in each group.The control group was treated with Valsartan alone,and observation group combined with Atorvastatin,they were treated for 3 months.The blood lipid,renal function and inflammatory indexes before and after treatment of two groups were compared,and the clinical efficacy of two groups was compared.Result:After treatment,the low density lipoprotein cholesterol(LDL-C)and total cholesterol(TC)in observation group were lower than those of before treatment and control group,the differences were statistically significant(P<0.05).After treatment,the 24 h urinary protein volume,BUN,hs-CRP and TNF-αin two groups were all lower than those of before treatment,and observation group were lower than those of control group,the differences were statistically significant(P<0.05).The total effective rate of observation group was 92.86%(39/42),which was higher than 76.19%(32/42)of control group,the difference was statistically significant(χ2=4.459,P=0.035).Conclusion:Atorvastatin combined Valsartan is effective in the treatment of chronic nephritis,which can better regulate blood lipid,improve renal function and alleviate inflammatory reaction,it is worthy of popularizing.