磷酸肌酸钠治疗小儿轮状病毒肠炎合并心肌损害的疗效观察

Clinical effect of sodium phosphocreatine on rotavirus enteritis complicated with myocardial damage in children

目的观察磷酸肌酸钠治疗小儿轮状病毒肠炎合并心肌损害的疗效。方法选取2014~2016年该院治疗的轮状病毒肠炎合并心肌损害患儿80例,随机分为对照组和观察组各40例。两组同时给予补液,纠正酸中毒,抗感染,纠正水电解质紊乱等对症常规治疗。观察组在此基础上加上磷酸肌酸钠治疗,1 g/次,0.9%氯化钠稀释后静脉治疗滴注,1次/d,7 d为一个疗程。结果两组患儿在治疗后心肌酶、心电图、心肌肌钙蛋白指数均有所下降,对照组中心肌酶CK-MB、LDH-1、HBDH分别为(44.5±12.3)U/L、(180.2±13.8)U/L、(255.46±63.22)U/L,心电图恢复正常率为75.0%,心肌肌钙蛋白为(0.11±0.03)U/L,观察组中心肌酶CKMB、LDH-1、HBDH分别为(32.3±6.7)U/L、(115.6±11.7)U/L、(220.31±36.53)U/L,心电图恢复正常率为92.5%,心肌肌钙蛋白为(0.05±0.01)U/L,观察组疗效更加明显,两组比较差异均有统计学意义(P<0.05)。结论注射用磷酸肌酸钠治疗小儿轮状病毒肠炎合并心肌损害具有良好疗效,值得推广应用。

Objective To observe the curative effect of sodium phosphocreatine on rotavirus enteritis complicated with myocardial damage in children.Methods 80 children with rotavirus enteritis complicated with myocardial damage treated in our hospital from 2014 to 2016 were randomly divided into the control group(n=40)and the observation group(n=40).Fluid infusion,correction of acidosis,water electrolyte disorder and antiinfection were given to the two groups.Besides the above routine treatments in the two group,the observation group was treated with sodium phosphocreatine,1 g+0.9%sodium chloride,intravenous drip,once daily,7 days for a treatment course.Results After the treatment,myocardial enzyme CK-MB,LDH-1 and HBDH were(44.5±12.3)U/L and(180.2±13.8)U/L and(255.46±63.22)U/L in the control group respectively,and(32.3±6.7)U/L,(115.6±11.7)U/L and(220.31±36.53)U/L in the observation group respectively.The recovery rate of electrocardiogram was 75.0%in the control group and 92.5%in the observation group.The level of cardiac troponin was(0.11±0.03)U/L in the control group and(0.05±0.01)U/L in the observation group.The treatment was more effective in the observation group than that in the control group(P<0.05).Conclusion Injection of sodium phosphocreatine is effective for the children with rotavirus enteritis complicated with myocardial damage.