烟曲霉生物膜研究进展

Research progress of Aspergillus fumigatus biofilms

近年来侵袭性曲霉病的发病率逐年上升,因其极高的致死率而引起了临床上广泛的关注。研究发现烟曲霉的生物膜形态是其重要致病形态。生物膜一旦形成其对多种抗真菌药物的耐药性、致病性将增加。这可能是导致临床高死亡率最直接的原因。该文主要从烟曲霉生物膜形成特点、致病性及其耐药机制和目前主要的生物膜研究方法等方面进行综述。

The frequency of invasive aspergillosis had dramatically increased year after year andthe high mortality rate had caused extensive concern of clinicians.The biofilm morphology which had been wildly recognized could enhanced pathogenicity to host and increase resistance to antimicrobial agents.Therefore,Biofilms might play an important role in causing high mortality rates.This review discussed the characteristics of Aspergillus fumigatus biofilm formation,biofilm detection methods and its mechanisms of drug resistance.