PD患者脑脊液尿酸与后续行为和认知能力下降间的关联性

Association of Cerebrospinal Fluid Uric Acid with Subsequent Behavioral and Cognitive Decline in PD Patients

目的:探讨脑脊液尿酸水平与帕金森病患者后续行为及认知能力间的关联性。方法:选取本院2015年3月-2016年3月收治的PD患者26例为观察组,并根据疾病严重程度分为A、B、C三组。选取同期来本院体检的健康者12例为对照组,所有患者均随访18个月,并进行后续行为及认知能力评估,比较不同组别患者间脑脊液尿酸水平。结果:经随访18个月,观察组PD患者后续行为明显加重,认知能力水平均有明显下降,比较差异有统计学意义(P<0.05);不同时期观察组患者尿酸水平均明显低于对照组,比较差异有统计学意义(P<0.05);观察组18个月后患者尿酸水平明显低于入组时,比较差异有统计学意义(P<0.05);观察组C组患者尿酸水平均明显低于A、B两组,疾病越严重尿酸水平越低,比较差异均有统计学意义(P<0.05)。结论:PD患者的脑脊液尿酸水平与后续行为和认知能力具有一定的相关性,可能成为诊断PD患者非运动症状的新指标,为PD的治疗提供新思路。

Objective:To investigate the relationship between serum uric acid level and subsequent behavior and cognitive ability in patients with Parkinson’s disease.Method:26 patients with PD in our hospital from March 2015 to March 2016 were selected as observation group,according to the severity of the disease,they were divided into three groups,group A,B and C.12 healthy people who came to our hospital for the same period were selected as the control group.All patients were followed up for 18 months,the follow-up behavior and cognitive ability assessment,the levels of uric acid in cerebrospinal fluid were compared among different groups.Result:The patients were followed up for 18 months,the follow-up behavior of PD patients in observation group was obviously aggravated,cognitive ability decreased significantly,the differences were statistically significant(P<0.05).The uric acid levels of the observation group were significantly lower than those of the control group at different stages,the difference was statistically significant(P<0.05).After 18 months,the uric acid levels of observation group was significantly lower than that of entering group,the difference was statistically significant(P<0.05).In observation group,the uric acid levels of group C were significantly lower than those of A and B group,the more serious the disease is,the lower uric acid levels are,the difference was statistically significant(P<0.05).Conclusion:The level of serum uric acid in patients with PD has a certain correlation with subsequent behavior and cognitive ability.It may become a new marker for the diagnosis of non motor symptoms in PD patients,providing new ideas for the treatment of PD.