帕金森病非运动症状的研究进展

Research progress on non motor symptoms of Parkinson's disease

帕金森病(PD)以运动障碍为主要表现。长期以来,改善运动症状是PD的治疗目标。但实践中,PD还会出现诸如感觉症状、睡眠障碍、自主神经功能紊乱及行为障碍等症候群,即非运动症状(NMS)。PD患者98.6%至少有1项NMS,且NMS的出现频率随病程及严重程度增加而上升。NMS存在于PD各期,严重影响患者的生活质量,故PD NMS的诊治应愈发受到重视。

Parkinson's disease(PD)is mainly characterized by dyskinesia.For a long time,improvement of exercise symptoms is the target of treatment for PD.But in practice,PD also has non motor symptoms(NMS),such as sensory symptoms,sleep disorders,autonomic nervous dysfunction and behavioral disorders.98.6%of PD patients has at least one NMS,and the frequency of NMS is increased with the increase of the course and severity.NMS exists at all stages of PD,which seriously affects the quality of life of the patients,therefore,the diagnosis and treatment of PD NMS should be paid more and more attention.