彩色多普勒颅脑超声对新生儿脑病的早期诊断价值

The early diagnostic value of color Doppler craniocerebral ultrasound on neonatal encephalopathy

目的探讨彩色多普勒颅脑超声在新生儿脑病早期诊断中的临床应用价值,为新生儿脑病患儿的早诊早治提供依据。方法选择新生儿脑病患儿92例为病例组(轻度组81例,中重度组11例),另选取同期住院的非新生儿脑病的新生儿42例为对照组。二维颅脑超声观察颅内结构,同时应用彩色多普勒技术检测新生儿大脑中动脉收缩期峰值流速(peak systolic velocity,PSV)、舒张末期血流速度(end diastolic velocity,EDV)和阻力指数(resistance index,RI)。结果轻度新生儿脑病患儿81例中二维颅脑超声发现异常者51例(63.0%),中重度新生儿脑病患儿11例中二维颅脑超声发现异常者9例(81.8%),对照组新生儿42例中二维颅脑超声检查均未见明显异常。轻度组PSV和EDV低于对照组,中重度组PSV和EDV低于对照组和轻度组,中重度组RI高于对照组和轻度组,差异均有统计学意义(P<0.05)。结论颅脑超声在新生儿脑病的早期诊断中具有重要价值。

Objective To explore the clinical value of color Doppler ultrasound in the early diagnosis of neonatal encephalopathy,and provide the basis for early diagnosis and treatment of neonatal encephalopathy.Methods The 92 neonates with neonatal encephalopathy were selected as case group(the mild and the moderate to severe groups),and 42 neonates without neonatal encephalopathy during the same period were randomly selected as control group.All these neonates received cranial ultrasound to detect intracranial structure and the brain blood flow.And all the cerebral hemodynamics parameters of middle cerebral artery which include peak systolic velocity(PSV),end diastolic velocity(EDV)and resistance index(RI)were measured via color Doppler flow.Results According to the results of two-dimension(2-D)Cranial ultrasonography(cUS),51 cases of the mild group were abnormal(63.0%).9 cases of the moderate to severe group were abnormal(81.8%).cUS findings were normal in 42 neonates of control group.The color Doppler flow cUS results showed that PSV and EDV of the mild group were lower than that in control group and that PSV and EDV of the moderate to severe group were lower than that in control group and also the mild group,while RI was higher.There were significant differences between groups(P<0.05).Conclusion cUS,using color Doppler flow on the basis of 2-D is of great value in early diagnosing of neonatal encephalopathy in neonates.