脑胶质瘤手术边界确认的研究新进展

New advance in the study of glioma boundary recognition

脑胶质瘤是颅内最常见的恶性肿瘤,肿瘤呈浸润性生长是其最显著的特点,导致肿瘤组织与正常组织界限不清,因此手术全切肿瘤困难,残存的肿瘤细胞又构成了复发的基础。胶质瘤手术的目的是在维持或改善神经功能的前提下达到最大限度地切除病灶。为了实现这一目标,急需一种确定脑胶质瘤边界的方法。本文将对术前辅助技术(多种术前磁共振成像、血氧水平依赖功能磁共振成像、^(11)C-蛋氨酸-PET/CT)和术中辅助技术(超声及超声造影、术中磁共振成像、神经定位导航、荧光造影)在确认脑胶质瘤边界方面的研究进展作一综述。

Glioma is the most common malignant brain intracranial tumor.The most significant characteristic of glioma is their diffuse invasion into the surrounding healthy tissue,which results in the unclear boundary between tumor and healthy tissue.Therefore total resection of glioma is difficult,and the remaining tumor cells form the basis of recurrence.The purpose of glioma surgery is to maximize the removal of the lesion in the context of maintenance or improvement of neurological function.In order to achieve this goal,a method for determining the boundary of glioma is urgently needed.This manuscript will review the use of preoperative adjuvant techniques[eg.preoperative magnetic resonance imaging(MRI),blood oxygen level dependent functional magnetic resonance imaging(BOLD-fMRI),11 C-methionine-PET/CT]and intraoperative assisted techniques[eg.ultrasound and ultrasound angiography,intraoperative magnetic resonance imaging,neural navigation and positioning technology,fluorescence angiography]in confirming the boundary of glioma.