电针对急性期脑梗死患者血清HIF-1α、VEGF水平的影响

Effect of Electroacupuncture on Levels of Serum HIF-1α and VEGF in the Treatment of Patients with Acute Cerebral Infarction

目的探讨电针治疗急性期脑梗死的临床疗效及对血清中缺氧诱导因子-1α(HIF-1α)及血管内皮生长因子(VEGF)水平的影响。方法将60例急性期脑梗死患者随机分为电针组及对照组,对照组采用西医常规治疗,电针组在西医常规治疗的基础上加用电针,观察治疗前后NIHSS评分及Barthel评分的变化情况,及血清低氧诱导因子-1ɑ(HIF-1α)及血管内皮生长因子(VEGF)水平。结果 2组患者临床疗效比较,电针组总有效率(88.46%)高于对照组(62.50%,P<0.05);2组治疗后NIHSS评分及Barthel评分均有改善(P<0.01),电针组优于对照组(P<0.05);2组治疗后血清HIF-1α水平都低于治疗前(P<0.01),VEGF水平都高于治疗前(P<0.01),电针组较对照组更为明显(P<0.05)。结论电针治疗急性期脑梗死患者可明显提高其临床疗效,并且显著降低HIF-1α的表达及促进VEGF的表达。

OBJECTIVE To explore the clinical effect of electroacupuncture in the treatment of acute cerebral infarction and its influence on the levels of serum hypoxia inducible factor 1 alpha(HIF 1α)and vascular endothelial growth factor(VEGF).METHODS 60 patients with acute cerebral infarction were randomly divided into the electroacupuncture group and the control group.The control group was treated the conventional western medicine,and the control group was also treated with the electroacupuncture on the basis of the control group.The changes of NIHSS score and Barthel score,and the changes of HIF 1αand VEGF levels were observed before and after the treatment.RESULTS Comparing the clinical effect of patients in both groups,the total effective rate of the electronic group(88.46%)was higher than that of the control group(62.50%,P<0.05).NIHSS score and Barthel score in both groups were improved after the treatment(P<0.01),and the electroacupuncture group was better than the control group(P<0.05).After the treatment,serum HIF 1αlevels in both groups were lower than those of the pre treatment(P<0.01),VEGF levels were higher those of the pre treatment(P<0.01),and the electroacupuncture group was improved more significantly than the control group(P<0.05).CONCLUSIONS The electroacupuncture can obviously improve the clinical effect in the treatment of patients with acute cerebral infarction,significantly decrease the HIF 1αexpression and promote VEGF expression.