NLR和PLR与成人斯蒂尔病的相关性分析

Correlation analysis of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio with adult onset disease

目的探讨中性粒细胞/淋巴细胞比值(NLR)和血小板/淋巴细胞比值(PLR)与成人斯蒂尔病(AOSD)的相关性。方法回顾性分析2013年7月至2017年8月在西南医科大学附属医院确诊为AOSD的50例患者的临床资料,根据是否合并感染分为非感染组27例和感染组23例。另选取同期健康体检人员47例作为对照组。检测所有研究对象血常规相关参数、红细胞沉降率(ESR)和C反应蛋白(CRP)的水平,分析各指标的相关性。结果与对照组比较,AOSD患者无论是否伴感染,其NLR、PLR均明显升高,且感染组NLR高于非感染组,差异有统计学意义(P<0.05)。NLR、PLR与AOSD系统评分呈正相关,非感染组NLR、PLR与CRP、ESR呈正相关。预测AOSD是否合并感染在NLR为10.86时诊断效能最高,此时敏感度为65.2%,特异度为77.8%。结论 NLR和PLR可以作为AOSD病情及炎症活动的评估指标,NLR对于指导是否合并感染有一定的诊断效能。

Objective To explore the correlation analysis of neutrophil to lymphocyte ratio(NLR)and platelet to lym?phocyte ratio(PLR)with adult onset disease.Methods A retrospective method was adopted in this study.Fifty patients in the Affiliated Hospital of Southwest Medical University from July 2013 to August 2017 was collected and divided into uninfected group(27 cases)and infected group(23 cases)according to the infection.In addition,47 patients were selected as the control group.The relevant parameters of blood routine,ESR,and CRP are analyzed.Result Compared with controls,NLR and PLR were significantly higher in AOSD groups whether or not with infection,NLR in infected group were significantly higher than that in the uninfected group(P<0.05).NLR and PLR have a positive correlation with AOSD systemic score,both NLR and PLR in AOSD uninfected were positively correlated with CRP and ESR respectively.NLR value of 10.86(sensitivity 65.2%,specificity 77.8%)was maximum diagnostic efficacy when forecast AOSD whether or not with infection.Conclusion NLR and PLR can be used as indicators for the condition and inflammatory activity in AOSD,and NLR have the diagnostic efficacy when judge AOSD whether or not with infection.