体重指数与多发性硬化发病的相关性分析

Correlation analysis between body mass index and the pathogenesis of multiple sclerosis

目的分析多发性硬化(MS)及临床孤立综合征(CIS)患者体重指数(BMI)水平,探讨BMI在MS及CIS发生中所起的作用。方法选取2013年1月至2017年7月在该院神经内科住院治疗的91例MS患者和4例CIS患者作为MS组。另选取同期该院体检中心的健康体检者127例作为HC组。采用扩展残疾状况量表(EDSS)评定MS及CIS患者的残疾状况,并分析MS及CIS发生与BMI的关系。结果 BMI>24 kg/m2在MS总人群(OR=1.47)、男性(OR=2.49)、女性(OR=1.16)中均为MS的危险因素。>20~50、>60~70岁年龄段BMI>24 kg/m2为MS的危险因素,MS组患者中EDSS评分与BMI呈正相关(r=0.42,P<0.05)。结论 MS好发于女性,好发年龄在大于20~50、>60~70岁,BMI>24 kg/m2是MS的危险因素,且MS患者神经功能损伤程度与BMI呈正相关。

Objective To analyze the body mass index(BMI)levels in patients with multiple sclerosis(MS)and clin ically isolated syndrome(CIS),and to explore the role of BMI in the pathogenesis of MS and CIS.Methods Ninety patients with MS and 4 patients with CIS in the Department of Neurology from January 2013 to July 2017 were selected as the MS group,and 127 healthy examinees were collected as the HC group.The disability status of MS and CIS patients was assessed using the expanded disability status scale(EDSS).The correlation between BMI and MS was analyzed.Results The predilection age of MS was>20~50 and>60~70 years old.BMI>24 kg/m2 was a risk factor in the MS population(OR=1.47),male(OR=2.49),and female(OR=1.16).There was a positive correlation between EDSS score and BMI value in MS group(r=0.42,P<0.05).Conclusion MS usually occur in the female of>20~50 and years old,BMI>24 kg/m2 is the risk factor of MS,and the degree of MS nerve function damage is positively correlated with BMI value.