噬血细胞综合征1例报道并文献复习

Hemophagocytic syndrome:a case report and literature review

目的分析1例成人噬血细胞综合征(HPS)的临床表现、诊断、鉴别诊断和预后。方法回顾性分析1例诊断为HPS的患者的临床资料,结合目前HPS的研究进展进行文献复习。结果本研究对象为一名19岁男性患者,以"发热伴咳嗽、咳痰1周"为主要表现入院,对症治疗后仍反复高热;综合症状、体征及实验室检查,最后诊断为噬血细胞综合征,经专科治疗,顺利出院,无后遗症。结论高热、白细胞降低不仅见于急性感染性疾病,也可见于噬血细胞综合征,提示我们早期需做好鉴别诊断以免误诊误治。

Objective To analyze the clinical manifestations,diagnosis,differential diagnosis and prognosis of an adult patient with hemophagocytic syndrome(HPS). Methods The clinical data of 1 patient diagnosed with HPS were analyzed retrospectively,and the review of literatures about current research progress of HPS was done. Results A 19-year old male patient presented mainly with fever,cough and expectoration for 1 week was hospitalized.After symptomatic treatment,he still had repeated high fever.He was diagnosed as hemophagocytic syndrome at last according to symptoms,signs and laboratory examinations synthetically.He was discharged from hospital without any sequelae after specialized treatment. Conclusion Hyperthermia and low leucocyte amount are not only seen in acute infectious diseases,but also in hemophagocytic syndrome,which suggests that early differential diagnosis must be done to avoid misdiagnosis and mistreatment.