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广西人群中IL-22基因启动子区rs2227513A/G位点多态性研究 被引量:1

A study of rs2227513A/G polymorphism in the promoter region of IL-22 gene in Guangxi population
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摘要 目的探讨广西正常人群中IL-22基因rs2227513A/G位点的多态性分布特点和不同人群间的多态性差异。方法采取多重单碱基延伸法(SNa Pshot)与DNA测序相结合的方法对280例广西人群的IL-22基因的rs2227513A/G位点进行基因分型检测,并用统计学方法比较不同性别及组间分布差异。结果广西人群中IL-22基因rs2227513A/G存在AA、AG基因型,分布频率分别为95.0%和5.0%,此位点基因型及等位基因频率在广西人群的男女性别间差异无统计学意义(P>0.05)。其基因型和等位基因与人类基因组计划项目(Hap Map)公布的意大利、墨西哥人群相比,差异有统计学意义(P<0.05),而与北京、日本人群比较,差异无统计学意义(P>0.05)。结论 IL-22基因rs2227513A/G基因多态性在不同种族和地区间存在差异。 Objective To study the distribution characteristic of rs2227513A/G polymorphism in Guangxi people and distribution difference with other ethnic groups.Methods rs2227513A/G loci of the IL-22 gene in 280 Guangxi people were examined by using SNaPshot technique and DNA sequencing,and distribution differences in different genders and groups were analyzed statistically.Results AA and AG genotypes were found in rs2227513A/G in Guangxi population,and distribution frequency was 95.0%and 5.0%,respectively.There was no statistically significant difference in genotype and allele frequency between different genders in Guangxi population(P>0.05).Compared with the distribution frequencies of genotype and allele in the population of Italy and Mexico which were published by human genome project(HapMap),difference was statistically significant(P<0.05),but not statistically significant compared with those in Beijing and Japan(P>0.05).Conclusion rs2227513A/G polymorphism of IL-22 gene has differences in different races and regions.
作者 王荣 黄华佗 陆玉兰 覃海媚 谭昙 雷茗 王俊利 韦叶生 WANG Rong;HUANG Huatuo;LU Yulan;QIN Haimei;TAN Tan;LEI Ming;WANG Junli;WEI Yesheng(Affiliated Hospital,Youjiang Medical University for Nationalities,Baise 533000,China)
出处 《右江医学》 2018年第1期1-4,共4页 Chinese Youjiang Medical Journal
基金 国家自然科学基金(81560552 81260234) 广西医疗卫生适宜技术开发与推广应用项目(S201650)
关键词 IL-22 单核苷酸多态性 种群 IL-22 single nucleotide polymorphism population
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