血清铁蛋白与肝脏疾病相关性研究

Study on correlation between serum ferritin and liver disease

目的探讨血清铁蛋白(SF)与肝脏疾病的相关性。方法选择广西桂东人民医院2016年5月至2017年6月收治的肝脏疾病患者196例,其中慢性肝炎75例,肝硬化66例,肝细胞癌55例,另选取同期健康体检者60例作为对照组,检测入选者SF、谷丙转氨酶(ALT)及谷草转氨酶(AST)水平,并分析其相关性。结果 SF水平由高到低依次为肝细胞癌>肝硬化>慢性肝炎>对照组,而ALT和AST水平由高到低依次为慢性肝炎>肝硬化>肝细胞癌>对照组,各组间SF、ALT、AST水平差异均有统计学意义(P<0.001)。肝病患者SF与ALT、AST水平呈正相关(P<0.05)。结论各种肝脏疾病患者SF水平有所不同,SF水平有助于反映患者的病情。

Objective To investigate relationship between serum ferritin(SF)and liver disease.Methods A total of 196 patients with liver diseases admitted to Guidong People’s Hospital from May,2016 to June,2017 were selected,which included 75 cases of chronic hepatitis,66 cases of cirrhosis and 55 cases of hepatocellular carcinoma.And 60 healthy subjects were selected as control group.Then,SF,alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels of the two groups were detected,and relationship between them was analyzed.Results From high to low,the levels of SF were liver cell carcinoma>liver cirrhosis>chronic hepatitis>control group,and the levels of ALT and AST were chronic hepatitis>liver cirrhosis>liver cell carcinoma>control group,difference of SF,ALT and AST levels among the groups was statistically significant(P<0.001).The levels of SF,ALT and AST in patients with liver disease were positively correlated(P<0.05).Conclusion The levels of SF in patients with various liver diseases are different,and the levels of SF can help to reflect patient’s condition.