甘肃四县市部分汉族人群中高尿酸血症与高血压的关联性

Association between hyperuricemia and hypertension in the Han Population of four counties and cities in Gansu Province

目的探讨甘肃地区汉族人群高尿酸血症与高血压的关联性。方法:按照分层整群随机抽样方法对甘肃省4县市兰州、肃南、高台、张掖的20~80岁常住居民4 312人进行问卷调查、体格检查以及实验室检测。根据高尿酸血症诊断标准将体检人群尿酸水平分为Q1,Q2,Q3,Q4水平,探讨不同性别尿酸水平与高血压的关联。结果多因素Logistics回归结果显示,男性高尿酸血症患者发生高血压的风险为尿酸正常者发生高血压风险的2.42倍。女性高尿酸血症患者发生高血压的风险为尿酸正常者发生高血压风险的1.98倍。男性尿酸的Q3、Q4水平与Q1水平相比,尿酸水平与高血压关联有统计学意义(Q3,AOR=1.83,95%CI=1.32-2.53;Q4,AOR=2.76,95%CI=1.97-3.85);女性尿酸的Q3、Q4水平与Q1水平相比,尿酸水平与高血压关联有统计学意义(Q3,AOR=1.65,95%CI=1.13-2.39;Q4,AOR=2.61,95%CI=1.54-4.43)。结论尿酸水平与高血压患病率存在关联性,应在健康体检人群推行血尿酸常规筛查,及早发现和治疗高尿酸血症,以预防高血压的发生。

Objective To investigate the association between hyperuricemia and hypertension in the Han Population of four counties and cities in Gansu Province.Methods A total of 4 312 individuals aged 20 to 80 were selected by using stratified random cluster sampling method from four counties/cities in Gansu Province:Lanzhou,Sunan,Gaotai,Zhangye.Questionnaire survey,physical examination and laboratory test"were conducted among the participants.All participants’uric acid samples were divided into Q1,Q2,Q3 and Q4 levels according to the diagnostic criteria.Association between uric acid level and blood pressure was analyzed.Results Logistics regression analysis revealed that the risk of hypertension in male with hyperuricemia was 2.42 times higher than those with normal uric acid.The risk of hypertension in female with hyperuricemia was 1.98 times higher than those with normal uric acid.Additionally,among male participants,as compared with Q1 level of uric acid,Q3 and Q4 levels were significantly associated with hypertension.(Q3,AOR=1.83,95%CI=1.32-2.53;Q4,AOR=2.76,95%CI=1.97-3.85).Likewise,among female participants,as compared with Q1 level of uric acid,Q3 and Q4 levels,were significantly associated with hypertension.(Q3,AOR=1.65,95%CI=1.13-2.39;Q4,AOR=2.61,95%CI=1.54-4.43).Conclusion The level of uric acid was proved to be correlated with the prevalence of hypertension,therefore,the routine screening of serum uric acid should be carried out among healthy people,to detect and treat hyperuricemia and prevent the occurrence of hypertension.