环磷酸腺苷反应原件相关蛋白对抑郁症脑部区域特异性的研究进展

Progress in the study of regional specificity of adenosine cyclic monophosphate response-element-binding-protein to the brain of depression

环磷酸腺苷(c AMP)反应原件相关蛋白(CREB)是转录因子蛋白家族成员,在所有脑细胞内表达。CREB定位在细胞核,能够将发生在细胞膜上的刺激信号转换成细胞核内基因表达的改变,在刺激-转录偶联中发挥重要作用。CREB通过调控基因表达来调节各种神经蛋白的表达,最终影响单个神经元或整个神经循环的功能,是多种抗抑郁药物发挥治疗作用的靶点。研究表明大脑不同区域内的CREB对抑郁症的影响不同。笔者综述CREB调节基因转录的分子机制,重点阐述CREB在抑郁症发生、发展过程中作用的多样性,从而探讨CREB对该疾病潜在的治疗价值。

Cyclic adenosine monophosphate(cAMP)-response-element-binding proteins CREB is a member of transcription factors protein family and is expressed in all brain cells.With a location in the nucleus,CREB could transform stimulation in the cell membranes into gene expression alteration in the nucleus,which is crucial for stimulus-transcription coupling.With the gene exoression regulation fuction,CREB could regulate the expression of nearly all types of neuronal protein and ultimately affect the function of individual neurons and entire neuronal circuits,so that CREB has been the treatment target of a variety of antidepressants.Studies showed that the effects of CREB on depression can differ in different brain areas.The purpose of this article is to present a overview of the molecular mechanisms of CREB regulating gene transcription,to highlight the diversity of function of CREB on the occurrence and development of depression,and to explore the potential therapeutic value of CREB in depression.