肺癌辅助诊断中血清肿瘤标志物检测的价值研究

Study on the value of serum tumor markers in the diagnosis of lung cancer

目的探讨肺癌辅助诊断中应用血清肿瘤标志物检测的价值。方法选取江苏省常州市金坛区中医医院2013年1月至2016年7月收治的50例肺癌患者、50例肺部良性病变患者作为研究对象,将其设置为肺癌组、良性组,另选取同期接受健康体检者50例作为对照组。采集三组研究对象的空腹静脉血,对血清鳞状上皮细胞癌抗原(SCC)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段21-1(CYFRA21-1)、糖类抗原125(CA125)这5种血清肿瘤标志物的表达水平进行血清学检测,并计算单项检测与5项联合检测对肺癌的诊断准确性、灵敏度、特异度。结果肺癌组患者的SCC、CEA、NSE、CYFRA21-1、CA125等血清肿瘤标志物的表达水平均明显高于良性组及对照组,差异均有统计学意义(P<0.05);而良性组与对照组的各项标志物表达水平比较,差异无统计学意义(P>0.05)。5项联合检测的诊断准确性、灵敏度均明显高于单项检测,差异有统计学意义(P<0.05);单项检测、5项联合检测对肺癌的诊断特异度均达到90.00%,比较差异无统计学意义(P>0.05)。结论采用血清肿瘤标志物检测对肺癌进行辅助诊断具有良好的灵敏度及准确性,可对肺癌与肺部良性病变有效区分,其诊断价值显著。

Objective To investigate the value of serum tumor markers in the diagnosis of lung cancer.Methods A total of 50 cases of lung cancer patients and 50 patients with benign lung disease in Traditional Chinese Medicine Hospital of Jintan during January 2013 to July 2016 were selected as the subjects,regarding them as lung cancer group and benign group respectively,and 50 healthy physical examination people were selected as the control group.Fasting venous blood were collected and tested with serum squamous cell carcinoma antigen(SCC),carcinoembryonic antigen(CEA),neuron specific enolase(NSE),cytokeratin 19 fragment 21-1(CYFRA21-1)and carbohydrate antigen 125(CA125).The diagnostic accuracy,sensitivity,specificity of every single detection and five joint detection of lung cancer were caculated.Results The serum tumor marker expression levels of SCC,CEA,NSE,CYFRA21-1 and CA125 in lung cancer group were statistically higher than those in benign group and control group(P<0.05),and no significant was difference found between the benign group and control group(P>0.05).The diagnostic accuracy and sensitivity of joint detection were significantly higher than that of the single detection(P<0.05),and the specificity of lung cancer were 90.00%in single detection and combined detection,no significant difference found between single detect and joint detection(P>0.05).Conclusion The serum tumor markers have good sensitivity and accuracy of lung cancer diagnosis,it can help to distinguish lung cancer from benign lung lesions,and its diagnostic value is significant.