促性腺激素释放激素激动剂对早期宫颈癌行保留卵巢根治术患者的作用

Effects of gonadotropin releasing hormone agonist on ovarian function in patients with early stage cervical cancer undergoing ovarian preservation

目的探究促性腺激素释放激素(GnRH)激动剂对早期宫颈癌行保留卵巢根治术患者卵巢功能的保护作用。方法选取该院2015年1月至2016年1月收治的80例早期宫颈癌患者作为研究对象,随机分为对照组和观察组,每组各40例,观察组患者进行保留卵巢根治术,同时给予GnRH激动剂治疗,对照组患者仅进行保留卵巢根治术,比较两组患者化疗前后基础卵泡刺激素(bFSH)、血清抗苗勒管激素(AMH)、基础雌激素(bE2)水平和基础窦状卵泡数(bAFC)。结果两组患者化疗前bFSH、bE2、AMH水平和bAFC差异均无统计学意义(P>0.05);化疗后,观察组患者bFSH和bE2水平均明显低于对照组,AMH水平和bAFC均明显高于对照组,差异均有统计学意义(P<0.05);化疗后,两组患者bFSH水平均高于化疗前,bE2、AMH水平和bAFC均低于化疗前,差异均有统计学意义(P<0.05)。结论 GnRH激动剂可以有效保护早期宫颈癌行保留卵巢根治术患者的卵巢储备功能,值得临床进一步推广应用。

Objective To investigate the protective effect of gonadotropin releasing hormone(GnRH)agonist on ovarian function in patients with early stage cervical cancer undergoing ovarian preservation.Methods A total of 80 cases of early stage cervical cancer in the hospital from January 2015 to January 2016 were selected as subjects,they were randomly divided to observation group and control group,40 cases in each group.Patients in the observation group received ovarian preservation and GnRH agonist treatment,the control group patients received ovarian preservation only.The basal follicle stimulation hormone(bFSH)levels,serum anti Mullerian tube hormone(AMH)level,basic estrogen(bE2)levels,and the basal antral follicle number(bAFC)between two groups before and after chemotherapy were compared.Results There were no significant differences found between two groups in bFSH,bE2,AMH and bAFC before chemotherapy(P>0.05),but after chemotherapy,the bFSH and bE2 of observation group were statistically lower than that in control group(P<0.05),while AMH and bAFC of observation group were higher than that in control group,the difference were statistically significant(P<0.05).And after chemotherapy,the bSFH of both groups were statistically higher than before chemotherapy,while bE2,AMH and bAFC were lower than before chemotherapy,the difference were statistically significant(P<0.05).Conclusion GnRH agonists can effectively protect the early cervical cancer patients with radical resection of ovarian reserve and ovarian reserve function,it is worthy of further promotion in clinical application.