大黄联合奥曲肽治疗急性胰腺炎的疗效分析及安全性评价

Efficacy of Rhubarb Octreotide Rreatment of Acute Pancreatitis and Safety Evaluation

目的探讨大黄联合西药奥曲肽治疗急性胰腺炎的临床疗效,评价其安全性,为临床治疗提供借鉴。方法纳入急性胰腺炎患者124例,随机分为对照组和观察组,每组62例。对照组给予醋酸奥曲肽注射液治疗,观察组在对照组基础上加用中药大黄粉治疗。观察并比较两组临床疗效、APACHEⅡ评分及AMY、(LIP和Leptin水平等。)结果观察组总有效率显著高于对照组,差异具有统计学意义(P<0.05);两组患者治疗后APACHEⅡ评分均显著低于各组间治疗前,且观察组APACHEⅡ评分显著低于对照组,差异具有统计学意义(P<0.05);观察组血清AMY和LIP水平均显著低于对照组(P<0.05),血清Leptin水平显著高于对照组,差异具有统计学意义(P<0.05);观察组发热、呕吐、腹痛消失、腹部压痛消失等症状以及住院时间均显著低于对照组,差异具有统计学意义(P<0.05)。结论大黄联合奥曲肽治疗急性胰腺炎疗效显著,安全可靠,能有效抑制胰腺病理变化,缩短病程,改善患者预后,优于单用奥曲肽,值得临床推广应用。

Objective To evaluate the clinical efficacy of rhubarb combined with Western medicine octreotide treatment of acute pancreatitis,to evaluate its safety,aims to provide a reference value for clinical treatment.Methods A total of 124 cases of acute pancreatitis were randomly divided into a control group and observation group,62 cases in each group.The control group received octreotide acetate injection treatment,observation group were based on the use of traditional Chinese medicine Rhubarb treatment.Observe and compare the clinical efficacy of the two groups of patients,APACHEⅡscore and AMY,(LIP and Leptin levels,etc.)(Note that both the hospital laboratory we did not do)Results The total effective rate was significantly higher,with statistics learn the difference(P<0.05);after treatment APACHEⅡscores were significantly lower than before treatment between the groups,and the observation group APACHEⅡscore was significantly lower than the control group,the differences were statistically(P<0.05);observation AMY and LIP serum levels were significantly lower than the control group(P<0.05),serum Leptin levels were significantly higher,with a statistically significant difference(P<0.05);observation of fever,vomiting,abdominal pain,abdominal tenderness disappearance the symptoms and duration of hospitalization were significantly lower than the control group,with a statistically significant difference(P<0.05).Conclusion Rhubarb octreotide treatment of acute pancreatitis significant effect,safe and reliable,can effectively inhibit the pathological changes of the pancreas and duration,improve patient outcomes,better than octreotide,worthy of clinical application.