生长抑素与奥曲肽在肝硬化上消化道出血治疗中的应用对比研究

Comparative analysis of somatostatin and octreotide on upper gastrointestinal bleeding in patients with cirrhosis

目的对比生长抑素和奥曲肽对肝硬化上消化道出血的治疗效果。方法将86例肝硬化上消化道出血患者视为研究对象,根据治疗方法的不同将患者分为对照组(n=43)和研究组(n=43),对照组应用奥曲肽,研究组采用生长抑素,将两组的临床疗效进行对比。结果研究组的总有效率(95.35%)高于对照组(81.40%),差异有统计学意义(P<0.05)。研究组的不良反应发生率(6.98%)低于对照组(23.26%),差异有统计学意义(P<0.05)。研究组止血所用时间短于对照组,且研究组的输血量少于对照组,差异有统计学意义(P<0.05)。结论在肝硬化上消化道出血患者的治疗中,生长抑素对患者病情的缓解作用较好,止血速度较快,输血量少,且不良反应较少,应用价值较高。

Objective To investigate the clinical effectiveness of somatostatin and octreotide on upper gastrointestinal bleeding(UGB)in patients with cirrhosis.Methods A total of 86 patients with cirrhosis and UGB were divided into control group(n=43)and study group(n=43)according to their treatment.Patients in control group were treated with octreotide while patients in study group with somatostatin.Clinical effectiveness was analyzed in two groups.Results The overall rate of effectiveness in study group(95.53%)was higher than that in control group(81.40%)(P<0.05).The incidence of adverse reaction in study group(6.98%)was smaller than that in control group(23.26%)(P<0.05).Time used for hemostasis in study group was shorter than control group and the amount of blood transfusion in study group was less than control group(P<0.05).Conclusion In the treatment of UGB in patients with cirrhosis,somatostatin was of application value and beneficial for patients'disease with faster hemostasis,less amount of blood transfusion and less complications.