甘精胰岛素联合瑞格列奈治疗2型糖尿病临床疗效观察

Curative effect observation of treatment combining insulin glargine and repaglinide in patients with type-2 diabetes

目的探讨甘精胰岛素联合瑞格列奈治疗2型糖尿病的治疗效果。方法选择我院2016年3月~2017年6月间收治的2型糖尿病患者72例作为研究对象,按照电脑随机数分组的方案,将其随机分为两组,分别为对照组和实验组,每组36例患者。对照组患者采用单纯预混胰岛素进行治疗,而实验组患者则应用甘精胰岛素联合瑞格列奈进行治疗。对比两组患者的治疗效果,记录两组患者的空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)的数值,分析治疗效果。结果实验结果显示,实验组患者的治疗总有效率较对照组明显更高,差异具有统计学意义(P<0.05)。两组患者在治疗完成后,各项指标数据均有所改善,但实验组患者改善程度较对照组明显更优,差异具有统计学意义(P<0.05)。结论应用甘精胰岛素联合瑞格列奈对2型糖尿病患者进行治疗能够有效提高患者的治疗效果,缓解患者的临床症状,控制患者的各项血糖指标水平,具有较好的治疗效果,值得在临床上推广使用。

Objective To investigate the curative effect of treatment combining insulin glargine and repaglinide in patients with type-2 diabetes.Methods 72 patients with tyepe-2 diabetes in our hospital from March 2016 to June 2017 were selected and randomized into control group and study group according to grouping schemes generated through computer random number with 36 patients in each.Patients in control group were treated with pure premixed insulin while patients in study group were treated with insulin glargine and repaglinide.The curative effect of patients in two groups was compared.The levels of fasting plasma glucose(FPG),2-hour postprandial plasma glucose(2hPG)and glycosylated hemoglobin(HbA1c)in two groups were recorded to assess the curative effect.Results Results of this study showed the overall rate of effectiveness in study group was statistically higher than that in control group(P<0.05).The status of indicators in patients of both two groups improved whereas the status in study group improved more than control group(P<0.05).Conclusion Treatment combining insulin glargine and repaglinide in patients with type-2 diabetes could improve the curative effect,relive clinical symptoms and control the levels of blood glucose indicators.The curative effect was good and this treatment was worth clinical promotion.