普瑞巴林在慢性疼痛治疗中的应用

Application of pregabalin in the treatment of chronic pain

目的探讨普瑞巴林在慢性疼痛治疗中的应用效果。方法选取2014年2月~2016年4月收治的带状疱疹后遗神经痛患者52例,依据双盲分组法随机分两组,对照组26例给予常规药物布洛芬缓释胶囊治疗,观察组26例给予普瑞巴林治疗,比较两组临床效果。结果治疗前两组疼痛强度、睡眠质量无显著差异(P>0.05),服药后两组疼痛强度缓解、睡眠质量提高(P<0.05),但观察组较对照组更具优势(P<0.05);两组发生不良反应无显著差异(P>0.05)。结论普瑞巴林在慢性疼痛治疗中效果显著,未见严重不良反应,安全应用。

Objective To investigate the effect of pregabalin in the treatment of chronic pain.Methods 52 patients with postherpetic neuralgia after shingles of the patients with chronic pain admitted from February 2014 to April 2016 were selected and divided into two groups randomly according to the double-blind grouping method.In the control group,26 patients were given conventional drug ibuprofen release capsule treatment.And 26 patients in the observation group were given pregabalin treatment.The clinical effect between the two groups was compared.Results There was no significant difference in the pain intensity and sleep quality between the two groups before treatment(P>0.05).The pain intensity was relieved and the quality of sleep was improved in two groups after taking medicine(P<0.05),while the observation group had more advantages than the control group(P<0.05).There was no significant difference in the adverse reactions between the two groups(P>0.05).Conclusion Pregabalin has significant effect in the treatment of chronic pain without serious adverse reactions and should be safely used.