慢性萎缩性胃炎发病的危险因素与临床治疗效果评价

Risk factors and effectiveness evaluation of clinical treatment of chronic atrophic gastritis

目的分析慢性萎缩性胃炎发病的危险因素与临床治疗效果。方法选取2016年1月～2017年5月间我院收治的84例慢性萎缩性胃炎患者作为研究组,所有患者HP均为阳性,并选取同期来我院治疗的90例慢性非萎缩性胃炎患者作为对照组,应用Logistic回归分析慢性萎缩性胃炎患者的危险因素;按照治疗方式的不同将其分成两组,A组应用三联疗法与替普瑞酮治疗,B组在A组的基础上加叶酸进行治疗,对比分析两组患者的临床疗效。结果研究组中41例有家族胃癌史,23例胆汁反流,67例存在Hp感染,对照组中19例家族胃癌史,7例胆汁反流,39例Hp感染,以上均为慢性萎缩性胃炎的危险因素;经治疗后,B组的治疗总有效率为95.24%,明显高于A组的78.57%,组间差异有统计学意义(χ~2=5.1258,P<0.05)。结论慢性萎缩性胃炎的危险因素包括家族胃癌史、Hp感染与胆汁反流,在治疗方面,采用三联疗法+替普瑞酮+叶酸治疗的疗效更佳,能够有效改善患者的临床症状,具有较高的临床应用价值。

Objective To investigate the risk factors and effectiveness of clinical treatment of chronic atrophic gastritis(CAG).Methods 84 patients with CAG in our hospital from January 2016 to May 2017 were selected as the study group.The assessment of HP in all patients was positive.90 patients with chronic non-atrophic gastritis(CNAG)in our hospital during the same period were selected as control group.Logistic regression analysis was used to analyze the risk factors of CAG.Patient with CAG were divided into two groups according to different treatment.Study group A was treated with triple therapy and teprenone.Study group B was given folic acid additionally.The clinical effectiveness was compared between two groups.Results There were 41 cases with family history of gastric cancer,23 cases with bile regurgitation and 67 cases with Hp infection in study group.There were 19 cases with family history of gastric cancer,7 cases with bile regurgitation and 39 cases with Hp infection in the control group.Family history of gastric cancer,bile regurgitation and Hp infection were risk factors of CAG.After treatment,the overall effective rate of study group B was 95.24%,which was significantly higher than that of study group A(78.57%)(χ2=5.1258,P<0.05).Conclusion The risk factors of CAG include family history of gastric cancer,bile regurgitation and Hp infection.Regarding to its treatment,the effectiveness of triple therapy together with teprenone and folic acid was better.This treatment could improve patients’clinical symptoms and is worth applying in clinic.