侵袭性真菌感染的药物应用调查分析

Drugs for invasive fungal infection

目的 通过对注射用抗真菌药物的特点、作用机制、不良反应、耐药性等进行归纳阐述，为临床抗真菌药物的合理选用提供参考。方法 采用查阅资料、专著以及网络检索中国知网、维普数据等数据库，下载相应的文献，整理、统计分析。结果 检索的文献中涉及到抗真菌药物治疗的临床报道有741篇，其中有关侵袭性真菌感染治疗的有250篇，多烯类73篇，占29.2%；吡咯中的三唑类210篇，占84.0%；氟胞嘧啶类17篇，占6.8%；棘白菌素类33篇，占13.2%。结论 抗真菌药物在临床的应用越来越广泛，尤其是第3代唑类、棘白菌素类药物，已经成为系统性深部真菌感染、威胁生命的真菌、曲霉菌、念珠菌感染的一线治疗用药。

Objective To provide some references for the rational use of antifungal drugs by summarizing the characteristics,mechanism,adverse reactions,and drug resistance of antifungal drugs for injection.Methods The related data were searched from related literatures,works,and China National Knowledge Infrastructure and VIP databases and statistically analyzed.Results There were 741 clinical reports about the treatment of fungal infections,including 250 theses about treatment for invasive fungal infection.Among the 250 theses,73 theses(29.2%)had used polyene drugs,210(84.0%)triazole,17(6.8%)flurocytosine,and 33(13.2%)pneumocandins.Conclusions The application of antifungal drugs are more and more widely used;the third generation of azole drugs and flurocytosine drugs have become the first-line treatment drugs for deep fungal infections,especially for life threatening systemic fungus,aspergillus,and candida infections.