卡介菌多糖核酸对SLE患者辅助T细胞因子和疾病活动性的影响

Effects of polysaccharide nucleic acid fraction of bacillus calmette guerin(BCG-PSN)on the Th cytokines in patients with SLE and disease activity

为研究卡介菌多糖核酸(BCG-PSN)对SLE患者辅助T(Th)细胞因子及疾病活动性的影响,将SLE患者分为处理组34例和对照组32例,于治疗前后采用ELISA法检测患者血清中细胞因子水平,并评估疾病活动性。治疗后处理组γ-干扰素(IFN-γ)、白介素(IL)-4、IL-10均降至正常;治疗后对照组IFN-γ水平低于正常,而IL-4、IL-10水平仍高于正常,处理组疾病活动降低的程度明显优于对照组。提示BCG-PSN可作为SLE的一种辅助治疗方法。

This study was to investigate the effects of BCG-PSN on the Th cytokines and disease activity in patients with SLE.66cases were randomly divided into two groups,34cases in the treatment group treated with BCG-PSN plus corticosteroids and32cases in the control group treated with corticosteroids alone.Their serum IFN-γ?IL-4and IL-10levels were detected by ELISA before and after treatment.In the treatment group,serum IFN-γ?IL-4and IL-10lowered to normal;In the control group,serum IFN-γlowered as compared with normal control,but serum IL-4?IL-10were still higher than those in normal control.The disease activities in the treatment group were reduced much more than those in the control group.It was conclud-ed that BCG-PSN could adjust the levels of Th cytokines and help to relieve the disease activity of SLE.It indicated that immunomodulator BCG-PSN could be used to assist in treating SLE.