女性膀胱过度活动症(OAB)药物干预的临床研究

Clinical study of treating female OAB by drug intervention

目的探讨联用M受体阻滞剂与α受体阻滞剂相对于单一应用M受体阻滞剂对女性OAB的疗效影响。方法将受试对象随机分为两组,对照组(M受体阻滞剂,单用卫喜康,5mg,Q.d)63例患者,试验组(联合应用M受体阻滞剂与α受体阻滞剂,卫喜康5mg,q.d+哈乐0.2mg,q.d)63例,连续用药4-8周;嘱患者自行记录排尿日记。结果试验组组联合用药组临床症状改善效果比例(45/63)明显高于对照组(29/63)(P<0.01),两组之间因药物引起的副作用并未对患者身心和生活造成实质性差异性影响。结论卫喜康可以明显改善女性OAB症状,α受体阻滞剂可以高选择性作用于膀胱颈,达到松弛膀胱颈平滑肌作用,可在一定程度上改善患者下腹坠胀的症状;联用M受体阻滞剂与α受体阻滞剂相对于单一应用M受体阻滞剂治疗女性OAB可以达到更好的治疗效果。

Objective To study the effect of M receptor blockers and alpha receptor blockers with separate M receptor blockers on female OAB.Methods Subjects were divided into two groups at random.The control group(M receptor blocker,vesicar,5 mg,Q.d)were 63 patients.The Experimental group(M receptor blockers and alpha receptor blockers,vesicar,5mg,Q.d+Harold,0.2 mg,Q.d)were also 63 patients,drugs were used by 4 to 8 weeks continuously and micturition results were recorded by the patients themselves.Results The effect of experimental group(45/63)was obviously higher than control group(29/63)and the difference was statistically significant(P<0.01).The side effects caused by drugs of the two groups did not have a substantial difference in the physical and mental life of the patients.Conclusion Vesicar can obviously release the symptoms of OAB,alpha receptor blockers can have highly effect on bladder neck and relax the smooth the muscle of bladder,which can improve the symptoms of abdominal distension.The combination of M receptor blockers with alpha receptor blockers in the treatment of female OAB can achieve better effect than M receptor blockers alone.