肿瘤组织内肿瘤侵润淋巴细胞和前列腺癌术后复发的关系

Relationship between the Proportion of Tumor Infiltrating Lymphocytes in Tumor Mass and Postoperative Recurrence of Prostate Carcinoma

目的探讨前列腺癌肿瘤侵润淋巴细胞(TIL)与前列腺癌患者术后复发的关系,为临床上研究和预防前列腺癌术后复发提供理论及实验依据.方法采用流式细胞仪对81例前列腺癌根治术术后肿瘤组织内CD3^+、CD8^+、CD3^+CD4^+和CD3^+CD8^+TIL细胞进行测定分析,回顾性比较前列腺癌术后<3 a(A组)、3~5 a内(B组)及>5 a无复发(C组)的患者肿瘤组织内CD3^+CD8^+TIL细胞比例,对比分析各组前列腺癌术后复发与肿瘤组织内CD3^+CD8^+TIL细胞比例的关系.结果行前列腺癌根治术患者3 a内复发患者(A组)较3~5 a复发患者(B组)和5 a内无肿瘤复发患者(C组)CD3^+CD8^+TIL细胞比例明显较低(P<0.05),而C组患者CD3^+CD8^+TIL细胞比例较A、B 2组明显升高(P<0.05),3组患者中CD3^+、CD8^+、CD3^+CD4^+细胞比例则无明显统计学差异(P>0.05).结论对于可手术切除前列腺癌患者,其肿瘤内CD3^+CD8^+TIL细胞比例与前列腺癌术后复发有相关性,其可能作为监测前列腺术后复发的一个生物学指标,为临床预防或控制前列腺癌的术后复发转移提供新的思路.

Objective To investigate the relationship between proportion of Tumor infiltrating lymphocytes(TILs)in the prostate tumor mass and postoperative recurrence of prostate carcinoma in order to offer the theoretic as well as experimental basis for the prevention of postoperative recurrence in the prostate carcinoma.Methods The proportion of CD3+,CD8+,CD3+CD4+,CD3+CD8+TILs cells of 81PCa specimens underwent Radical prostatectomy were analyzed.The proportion of CD3+CD8+TILs in patients with recurrence of PCa within 3 years after surgery(group A),within 3～5 years(group B)and without recurrence after 5 years(group C)was compared.Results The proportion of CD3+CD8+TILs was significantly lower in group A than that of in group B and C(<0.05),meanwhile,the proportion of CD3+CD8+TILs were significantly higher in group C than that in group A and B(<0.05),while the proportion of CD3+,CD8+,CD3+CD4+in three groups had no significant difference(>0.05).Conclusion The proportion of CD3+CD8+TILs presented in the PCa specimen mass is relative to the postoperative recurrence of prostate cancer,which might be a biomarker for the surveillance of postoperative recurrence of PCa.