代谢健康人群脂肪肝的发生情况及其影响因素

Incidence and its influencing factors of fatty liver disease in population of metabolic health

目的了解代谢健康人群中脂肪肝的发生情况并分析其影响因素。方法选择代谢健康的2 349例体检者,其中经腹部B超诊断的脂肪肝患者283例作为脂肪肝组,2 066例无B超异常提示的体检者作为非脂肪肝组,比较两组的血压、血脂、血糖、ALT水平,采用logistic回归模型进行多因素分析。结果脂肪肝检出率为12.05%(283/2349),其中男性高于女性(P<0.05),>50岁者检出率高于≤50岁者(P<0.05)。脂肪肝组的SBP、DBP、FBG、TG、TC、LDL-C、ALT水平高于非脂肪肝组(P<0.05),HDL-C则低于非脂肪肝组(P<0.05)。性别、SBP、DBP、FBG、TG、LDL-C、ALT、HDL-C与代谢健康者发生脂肪肝相关(P<0.05),其中TG相对风险度最高(OR=5.370)。结论代谢健康人群的脂肪肝检出率较高,男性、血压、血脂、血糖偏高者更易发生脂肪肝。

Objective To investigate the incidence and its influencing factors of fatty liver disease in population of metabolic health.Methods A total of 2 349 individuals of metabolic health who receiving physical examination were enrolled,including 283 diagnosed as fatty liver disease by abdominal B-ultrasound(fatty liver group)and 2 066 without abnormal ultrasonic findings(non-fatty liver group).The blood pressure,blood lipid,blood glucose and ALT levels were compared between the two groups.Multivariate analysis was conducted using logistic regression model.Results The detection rate of fatty liver disease was 12.05%(283/2 349),and the rates in the males and the subjects older than 50 years were higher than the rates in the females and the subjects aged 50 years and younger respectively(P<0.05).The levels of SBP,DBP,FBG,TG,TC,LDL-C and ALT were higher but the HDL-C level was lower in the fatty liver group compared to the levels in the non-fatty liver group(all P<0.05).Gender,SBP,DBP,FBG,TG,LDL-C,ALT,HDL-C correlated with the incidence of fatty liver disease,and the relative risk of TG was the highest(OR=5.370).Conclusion The detection rate of fatty liver disease is high in the population of metabolic health,and the risk is higher in the males,or individuals with high pressure,increased level of blood lipid,blood glucose or ALT.