护心通络方对高脂血症模型大鼠血脂及血液流变学的影响

Effects of Huxin Tongluo Decoction on Blood Lipid and Blood Rheology in Hyperlipidemia Model Rats

目的观察护心通络方对高脂血症模型大鼠血脂、血液流变学指标的影响。方法 SPF级SD大鼠60只随机分成正常对照组,模型对照组,辛伐他汀组,护心通络方高、中、低剂量组6组。正常对照组喂普通饲料,其他各组喂养高脂饲料以建立高脂血症大鼠模型。各组大鼠按治疗方法给药30 d后,观察血清血脂以及血液流变学指标的变化。结果 (1)与模型对照组相比,护心通络方高、中剂量组均可明显降低大鼠的胆固醇(TC)、甘油三酯(TG)、低密度胆固醇脂蛋白(LDL-C)水平,明显升高高密度胆固醇脂蛋白(HDL-C)(P<0.05或P<0.01);(2)与模型对照组比较,护心通络方高、中、低剂量组的全血粘度(高、中、低切)、血浆粘度均下降,IEA(红细胞聚集指数)明显下降、IED(红细胞变形指数)明显升高,差异均有统计学意义(P<0.05或P<0.01)。结论护心通络方对高脂血症模型大鼠的血清血脂及血液流变学指标具有良好的调节作用。

Objective To observe the effect of Huxin Tongluo decoction on blood lipid and blood rheology in hyperlipidemia model rats.Methods Sixty SPF grade SD rats were randomly divided into 6 groups:normal control group,model control group,simvastatin group,high,medium and low doses of Huxin Tongluo decoction groups.The rats in normal control group were fed with normal diet,rats in other groups were fed with high fat diet to establish hyperlipidemia rat models.After administration for 30 days,the changes of serum lipids and hemorheological indexes were observed.Results(1)Compared with the model control group,the levels of cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)in medium and high doses of Huxin Tongluo decoction group decreased significantly,and the high-density lipoprotein cholesterol(HDL-C)increased significantly(P<0.05 or P<0.01).(2)Compared with the model control group,the whole blood viscosity(high,medium,low cut)and plasma viscosity of all Huxin Tongluo decoction groups decreased,the level of IEA(red cell assembling index)decreased significantly,and IED(red cell assembling index)increased significantly,the differences were statistically significant(P<0.05 or P<0.01).Conclusion Huxin Tongluo decoction shows a good regulating effect on serum lipid and hemorheology indexes in hyperlipidemia model rats.