槐耳颗粒配合肺叶切除术治疗原发性支气管肺癌的临床研究

Clinical Study of Huaier Particles Combined with Lobectomy on Patients with Primary Bronchogenic Carcinoma

目的研究槐耳颗粒配合胸腔镜肺叶切除术对原发性支气管肺癌患者的影响。方法选取2013年7月-2016年7月我院及承德医学院附属医院收治的原发性支气管肺癌患者96例,采用随机数字表法分为观察组与对照组,对照组患者采用胸腔镜肺叶切除术治疗,观察组患者采用槐耳颗粒配合胸腔镜肺叶切除术治疗,对比两组患者临床疗效、高血钙发生情况、血清钙水平、胰岛素样生长因子1(IGF-1)、白细胞介素-8(IL-8)和癌胚抗原(CEA)水平。结果观察组患者治疗总有效率100.0%,显著高于对照组87.5%(P<0.05);治疗后两组高血钙发生率及血清钙水平较治疗前均降低(P<0.05或P<0.01);观察组患者治疗后高血钙发生率2.1%显著低于对照组18.8%(P<0.01),血清钙水平明显低于对照组(P<0.05);两组患者治疗后IGF-1、IL-8和CEA水平均明显低于治疗前(P<0.01),且观察组显著低于对照组(P<0.01)。结论槐耳颗粒配合胸腔镜肺叶切除术能够有效提高原发性支气管肺癌患者治疗效果,降低IGF-1、血清钙、IL-8、CEA水平。

Objective To explore the effect of Huaier particles combined with thoracoscopic lobectomy for primary bronchogenic carcinoma patients.Methods 96 cases of patients with primary bronchogenic carcinoma treated in hospitals from July 2013 to July 2016 were selected,and were randomly divided into the observation group and control group according to random alphabet method.The control group were given thoracoscopic lobectomy treatment,and the observation group were given Huaier particles combined with thoracoscopic lobectomy.The clinical efficacy,the occurrence of hypercalcemia,serum calcium levels,Insulin-like growth factor 1(IGF-1),Interleukin-8(IL-8)and carcino-embryonic antigen(CEA)levels were compared between the two groups.Results The total effective rate of observation group was 100.00%,which was significantly higher than that of 87.50%in the control group(P<0.05).The incidence of hypercalcemia and level of serum calciumin after treatment decrased significantly(P<0.05 or P<0.01).The incidence of hypercalcemia 2.1%was lower than that of 18.8%in the control group(P<0.01),and serum calcium level in the observation group was significantly lower than that in the control group(P<0.05).The average levels of IGF-1,IL-8 and CEA in the two groups were significantly lower than that before treatment(P<0.01),and those in the observation group were significantly lower than those in the control group(P<0.01).Conclusion Huaier particles combined with thoracoscopic lobectomy can effectively reduce curative effect of primary bronchogenic carcinoma,and decrase the levels of IGF-1,serum calcium,and IL-8 and CEA levels.