2,2-二甲基-5-溴-1,3-二氧六环-4,6-二酮的合成研究

Synthesis of 2,2-Dimethyl-5-bromide-1,3-dioxane-4,6-dione

为了避免使用液溴作为溴化剂带来的种种弊端,以支载型溴盐和麦氏酸为原料合成了2,2-二甲基-5-溴-1,3-二氧六环-4,6-二酮。结果表明:三溴喹啉盐在乙醇中可以缓慢的释放溴素,对麦氏酸有很好的溴化效果,避免了使用液溴作为溴化剂带来的危害。目标产物结构经红外光谱(FT-IR)、元素分析、核磁共振氢谱(1H NMR)和核磁共振碳谱(13C NMR)测定和结构表征。此方法具有操作简单、环境友好、产率高的特点。

To overcome the disadvantages of using liquid bromine as a brominating agent,2,2-Dimethyl-5-bromide-1,3-dioxane-4,6-dione was synthesized from supported bromide salt and 2,2-Dimethyl-1,3-dioxane-4,6-dione.The results showed that tribromoquinoline salt could slowly release bromine in ethanol and 2,2-Dimethyl-1,3-dioxane-4,6-dione had a good effect of bromination.The hazards of using liquid bromine as a bromination agent can be avoided.The structure of the target product was confirmed by elementary analysis,FT-IR,1H NMR and 13 C NMR spectroscopy.This method has advantages of simple work-up procedure,eco-friendly and high yield.