血清Hcy对不稳定型心绞痛患者焦虑症发生的影响

Correlation analysis between degree of anxiety and serum homocysteine level in patients with unstable angina

目的探讨血清同型半胱氨酸(Hcy)水平对不稳定型心绞痛患者焦虑症发生的影响。方法纳入150例不稳定型心绞痛患者作为研究对象,采用焦虑自评量表(SAS)对其焦虑症进行调查,根据结果分为无焦虑组和焦虑组。抽取空腹肘正中静脉血2 ml检测Hcy,分析Hcy水平对焦虑症的影响。结果 150例不稳定型心绞痛患者中出现焦虑症68例,占45.3%。两组患者年龄、SAS评分、病程及Hcy水平比较,差异有统计学意义(P<0.05)。病程延长及Hcy水平升高是影响不稳定型心绞痛患者焦虑症的独立危险因素。轻度组Hcy水平及高同型半胱氨酸血症(HH)比例与中、重度组比较,差异有统计学意义(P<0.05);中度组Hcy水平及HH比例与重度组比较,差异有统计学意义(P<0.05)。相关性分析结果表明,Hcy水平随SAS评分增加而升高(P<0.05)。结论血清Hcy水平是不稳定型心绞痛患者焦虑症发生的危险因素,且与焦虑症严重程度呈正相关。临床上对存在血清Hcy水平升高的不稳定型心绞痛患者需要密切注意其情绪变化。

Objective To study the correlation between the degree of anxious state in patients with unstable angina and the serum homocysteine(Hcy)level.Methods Totally 150 patients with unstable angina were included.All patients were tested by the self-assessment lists of anxiety(Self-rating Anxiety Scale,SAS),and divided into nonanxiety group and anxiety group.The serum Hcy level was detected.Results There were 68 patients with anxiety in the 150 patients with unstable angina,accounting for 45.3%.The age,SAS score,disease course and Hcy level in the anxiety group were significantly different from that in the patients without anxiety(P<0.05).Prolonged disease course and increased Hcy level were the independent risk factors for anxiety of the patients with unstable angina(P<0.05).The Hcy levels and proportion of HH in the mild group were statistically lower than those in the moderate and severe groups(P<0.05).The Hcy level and proportion of hyperhomocysteinemia in the moderate group were significantly lower than those in the severe group(P<0.05).Correlation analysis showed that Hcy level increased with the increase of SAS score(P<0.05).Conclusions Hcy level is a risk factor for anxiety in the patients with unstable angina,and is correlated with the severity of anxiety.The unstable angina patients with elevated serum Hcy level should be closely watched for the emotional changes.