脑电生物反馈治疗对精神分裂症患者的影响

Effect of EEG biofeedback therapy on patients with schizophrenia

目的探讨脑电生物反馈治疗联合认知功能训练对精神分裂症患者认知功能的影响。方法前瞻性收集该院收治的精神分裂症患者92例,随机分为观察组和对照组,每组46例。两组给予认知功能训练,观察组在该基础上给予脑电生物反馈治疗。比较治疗前后两组患者认知功能的变化。结果治疗前两组患者β波、θ波、SMR比较,差异无统计学意义(P>0.05);治疗后观察组β波和SMR波升高(P<0.05),θ波降低(P<0.05)。治疗前两组患者定步调听觉连续加法测验评分比较,差异无统计学意义(P>0.05);治疗后观察组定步调听觉连续加法测验评分高于对照组(P<0.05)。治疗前两组患者持续错误数和完成分类数比较,差异无统计学意义(P>0.05);治疗后观察组持续错误数降低(P<0.05),完成分类数增加(P<0.05)。治疗前两组患者白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后观察组IL-6、TNF-α水平低于对照组(P<0.05)。结论脑电生物反馈治疗联合认知功能训练可改善精神分裂症患者的认知功能。

Objective To investigate the effect of electroencephalogram(EEG)biofeedback therapy combined with cognitive function training on the cognitive function of the patients with schizophrenia.Methods From January 2016 to June 2017,92 schizophrenic patients were randomly divided into an observation group and a control group with 46 cases in each group.Cognitive function training was given to both groups,while EEG biofeedback therapy was given to the observation group on the basis.The cognitive function of the two groups of patients before and after treatment was compared.Results There was no significant difference inβwave,θwave or SMR wave before treatment between the two groups(P>0.05).However,βwave and SMR wave increased(P<0.05),whileθwave decreased after treatment in the observation group when compared with the control group(P<0.05).There was no statistical difference between the two groups before treatment in the score of the constant step auditory continuous addition test(P>0.05).After treatment,the score of the constant step auditory continuous addition test was higher in the observation group when compared with the control group(P<0.05).There was no significant difference in the number of continuous errors or the completed classification number between the two groups before treatment(P>0.05).After treatment,the number of continuous errors decreased(P<0.05),and the completed classification number increased(P<0.05)in the observation group.There was no significant difference in IL-6 or TNF-αbetweenthe two groups before treatment(P>0.05).After treatment,the levels of IL-6 and TNF-αin the observation group were lower than those in the control group(P<0.05).Conclusions EEG biofeedback therapy combined with cognitive function training can improve the cognitive function in the patients with schizophrenia.