功能保留性胰腺手术对胰腺神经内分泌肿瘤的治疗效果

Effect observation of functional reserved pancreas surgery on treatment of pancreatic neuroendocrine neoplasms

目的:观察功能保留性胰腺手术治疗胰腺神经内分泌肿瘤(pancreatic neuroendocrine neoplasms,p NENs)的效果。方法:选择2013年1月至2016年3月收治的64例p NENs患者为研究对象,将其随机分为观察组和对照组,每组32例。观察组患者采用功能保留性胰腺手术,对照组患者采用胰腺十二指肠切除术(Whipple手术),比较两组患者手术时间、术中出血量、胃肠道通气时间、术后下床活动时间,采用卡氏功能状态标准评分(KPS评分)和生存质量测定简表(QOL-BREF评分)评价患者术后1个月时恢复状况,比较两组患者短期预后(1年生存率、1年复发率)。结果:观察组患者的手术时间、术中出血量、胃肠道通气时间、术后下床活动时间均低于对照组(P<0.05);术后1个月时,观察组患者的KPS评分、QOL-BREF评分均高于对照组(P<0.05);两组患者的1年生存率、1年复发率分别比较,差异均无统计学意义(P>0.05)。结论:功能保留性胰腺手术能有效治疗p NENs,具有手术创伤小、术后短期恢复快等优势,值得推广应用。

Objective:To investigate the clinic effect of functional reserved pancreas surgery on treatment of patients with pNENs.Methods:64 cases of pNENs from January 2013 to March 2016 were selected and divided into observation group and control group,32 cases in each group.The observation group was given functional reserved surgery,and the control group was given Whipple surgery.The surgery time,peroperative bleeding,gastrointestinal ventilation time,postoperative activity time,KPS score and QOL-BREF score 1 month after operation,and short-term prognosis including 1-year survival rate and 1-year recurrence rate were compared between the two groups.Results:①The surgery time,peroperative bleeding,gastrointestinal ventilation time,postoperative activity time of the observation group were all less than those of the control group(P<0.05);②1 month after surgery,KPS score and QOL-BREF score of the observation group were all higher than those of the control group(P<0.05);③There was no statistically significant difference in 1-year survival rate and 1-year recurrence rate between the two groups(P>0.05).Conclusion:Functional reserved pancreas surgery can be adopted in treating pNENs effectively,which is of the advantages in reducing intraoperative trauma of pNENs patients,and it has good postoperative short-term recovery.