酮替芬联合羧甲司坦治疗慢性阻塞性肺疾病稳定期不同证型患者的疗效

Efficacy of Ketotifen Fumarate tablets combined with Carbocisteine tablets on different syndromes types of patients with COPD

目的:观察慢性阻塞性肺疾病(COPD)稳定期不同证型患者对酮替芬联合羧甲司坦治疗的疗效情况。方法:选取COPD患者100例,随机分成观察组及对照组各50例,分为肺脾气虚型、肺肾气虚型、气虚血瘀型;对照组在常规治疗基础上服加羧甲司坦,观察组在对照组基础上加服酮替芬,均连用6个月;观察治疗前后两组患者的血生化指标、肺功能、6 min步行距离(6MWD)、BODE评分及CAT评分;记录发作次数及间隔时间。结果:治疗6个月后,观察组肺脾气虚型、肺肾气虚型患者的肺功能、6MWD、BODE评分及CAT评分改善情况均优于气虚血瘀型患者(P<0.05)。结论:酮替芬联合羧甲司坦对COPD稳定期患者的症状改善、发作控制方面有较好的疗效,可减少发作次数,延长疾病发作的间隔时间,改善患者的肺功能,尤其在肺脾气虚型及肺肾气虚型患者疗效优于气虚血瘀型患者。

Objective:To observe the efficacy of Ketotifen Fumarate tablets combined with Carbocisteine tablets on different syndromes types of patients with stable chronic obstructive pulmonary disease(COPD).Methods:100 patients with COPD were randomly divided into the treatment group and the control group,50 patients in each group,and patients were further divided into Qi deficiency of lung and spleen,Qi deficiency of lung and kidney,and Qi deficiency and blood stasis according to the standard of syndrome differentiation.The control group received conventional treatment and Carbocisteine tablets,while the treatment group additionally received Ketotifen Fumarate tablets.Both courses of treatment were six months.The serum biochemistry index,pulmonary function,6 minutes walk distance(6MWD),BODE index score and CAT score were recorded before and after treatment.The frequency of attacks and interval time were recorded.Results:After six months'treatment,the pulmonary function,6MWD,BODE index score and CAT score of patients with Qi deficiency of lung and spleen and Qi deficiency of lung and kidney in the treatment group were improved,better than those in patients with Qi deficiency and blood stasis(P<0.05).Conclusion:Ketotifen Fumarate tablets combined with Carbocisteine tablets could significantly improve the symptoms of stable COPD patients,reduce the frequency of attack,prolong the interval time of the acute attack and improve the pulmonary function,especially in the patients with Qi deficiency of lung and spleen and Qi deficiency of lung and kidney.