匹维溴铵联合氟哌噻吨美利曲辛治疗肠易激综合征伴抑郁焦虑的疗效

The effect of pinaverium bromide combined with flupentixol and melitracen in the treatment of irritable bowel syndrome with depression and anxiety

目的探讨匹维溴铵联合氟哌噻吨美利曲辛治疗肠易激综合征伴焦虑的临床效果。方法选取2016年1月~2017年8月在本院收治的120例肠易激综合征患者,随机分为两组,每组60例。对照组为单纯给予匹维溴铵口服;研究组采用用匹维溴铵联合氟哌噻吨美利曲辛治疗,两组均持续治疗8周。观察两组患者的GSRS、SDS、SAS评分、药物治疗效果、不良反应等。结果各组治疗后的GSRS、SDS、SAS评分均降低(P<0.05),而研究组比对照组治疗后的GSRS、SDS、SAS评分降低更明显,两组比较差异有统计学意义(P<0.05)。对照组疗效为75.0%,研究组疗效88.3%,两组之间比较差异无统计学意义(P>0.05)。同时两组在治疗期间没有任何患者出现不良反应。结论联合应用匹维溴铵和氟哌噻吨美利曲辛,既能改善胃肠道的症状,恢复肠道功能,也能够减轻焦虑抑郁状态,同时不良反应少,安全性高。

Objective To investigate the clinical effect of pinaverium bromide combined with flupentixol and melitracen in the treatment of irritable bowel syndrome with anxiety.Methods One hundred and twenty patients with irritable bowel syndrome treated in our hospital from January 2016 to August 2017 were randomly divided into two groups,with 60 cases in each group.The control group was given pinaverium bromide orally,the study group was treated with pinaverium bromide combined with flupentixol and melitracen treatment,two groups were treated for 8 weeks.The scores of GSRS,SDS,SAS,drug results and adverse reactions were observed in the two groups of patients.Results The scores of GSRS,SDS and SAS decreased after treatment in each group(P<0.05).The scores of GSRS,SDS and SAS in the study group were significantly lower than those in the control group,and the difference between the two groups was statistically significant(P<0.05).The effect of the control group was 75.0%,and the effect of the study group was 88.3%,there was no significant difference between the two groups(P>0.05).No adverse reactions were observed during treatment in both groups.Conclusion The combination of pinaverium bromide and flupentixol melitracen can not only improve gastrointestinal symptoms,restore intestinal function,but also reduce anxiety and depression,and has less adverse reactions and high safety.