参与多发性骨髓瘤发病的新成员:蛋白激酶CK2

A Novel Player in Multiple Myeloma Pathogenesis:Protein Kinases CK2

多发性骨髓瘤(MM)是一种恶性浆细胞病,发病后导致组织器官损伤和骨破坏,具有较高的死亡率。蛋白激酶CK2(酪蛋白激酶)是真核生物中普遍存在的丝氨酸/苏氨酸蛋白激酶,在肿瘤细胞增殖和血液肿瘤中起重要作用。CK2在恶性血液病包括慢性、急性白血病和多发性骨髓瘤中有致瘤作用,可通过调节多种关键的信号通路促进恶性肿瘤的生长。该文综述了CK2在多发性骨髓瘤中对NF-κB和STAT3信号通路及内质网应激(ERS)、未折叠蛋白反应(UPR)和热休克蛋白90的调节作用,并讨论其作为MM治疗靶点的可行性,为MM的预防及治疗提供理论依据。

Multiple myeloma(MM)is a plasma cell malignancy,which leads to a crucial mortality morbidity due to organ tissue damage and bone destruction.Protein kinase CK2(casein kinase)is a critically ubiquitous expressed in eukaryotes,which plays an important role in the pathogenesis of malignant cell growth and it is increasingly forming both in solid and blood tumors.In hematologic malignan-cies,CK2 has been shown to play an oncogenic function in chronic or acute leukemias and MM.It has been illustrated that CK2 can control the growth of malignant tumors via regulating various signaling pathways.This article briefly described the regulation effect of CK2 on NF-κB,STAT3 signaling pathway,endoplasmic reticulum stress(ERS),unfolded protein response(UPF)and heat shock protein 90 in multiple myeloma and discussed the treatment target feasibility of MM,and provided a theoretical support for MM prevention and treatment.