克唑替尼对晚期非小细胞肺癌患者外周血清基质金属蛋白酶9的影响

Effect of Crizotinib on Peripheral Serum MMP-9 in Patients with Advanced Non-Small-Cell Lung Cancer

目的观察克唑替尼对晚期非小细胞肺癌患者外周血清基质金属蛋白酶9(MMP-9)表达的影响。方法回顾性分析医院2015年1月至2016年12月收治的124例晚期非小细胞肺癌患者的临床资料,观察组(70例)患者采用克唑替尼治疗,对照组(54例)患者采用多西他赛治疗。均治疗2个疗程(42 d)。结果观察组总有效率为65.71%,明显高于对照组的42.59%(P<0.05);与治疗前比较,两组患者治疗后MMP-9表达均降低,观察组降低幅度更明显(P<0.05);两组患者生活质量评估(QOL)量表评分均下降,观察组下降幅度更大(P<0.05)。结论克唑替尼治疗非小细胞肺癌短期效果良好,对患者的生存质量影响较小,可改善血清MMP-9的表达,有利于延缓肿瘤细胞的侵袭、转移。

Objective To observe the effect of crizotinib on peripheral serum MMP-9 in patients with advanced non-small cell lung cancer(NSCLC).Methods Totally 124 patients with advanced NSCLC admitted to our hospital from January 2015 to December 2016 were patients were analyzed retrospectively,the observation group(n=70)was treated with crizotinib,the control group(n=54)was treated with docetaxel.The two groups were treated for two courses of treatment.Results The total effective rate in the observation group was 65.71%,which was significantly higher than 42.59%in the control group(P<0.05).After treatment,the expression of MMP-9 in the two groups were significantly decreased,and the decrease in the observation group was more significant(P<0.05).After treatment,the quality of life(QOL)scores in the two groups were significantly decreased,and the decrease in the observation group was more significant(P<0.05).Conclusion Crizotinib in the treatment of patients with advanced NSCLC has good short-term effect and less impact on the quality of life of patients,it can improve the expression of serum MMP-9 to a certain extent,which is beneficial to delay the invasion and metastasis of tumor cells.