尼莫地平联合多感官刺激技术治疗血管性痴呆的临床疗效及生活质量评价

Clinical efficacy and quality-of-life scale of nimodipine combined with multisensory stimulation technique in the treatment of vascular dementia

目的对尼莫地平联合多感官刺激技术治疗血管性痴呆(VaD)的临床疗效及安全性进行研究,并对患者生活质量进行评价。方法将本院收治的83例VaD患者随机数字表法分为对照组41例和治疗组42例,对照组患者在常规治疗的基础上口服尼莫地平片进行治疗,治疗组患者在对照组基础上联合多感官刺激技术进行治疗。采用简易精神状态评价量表(MMSE)和VaD评估量表-认知分量表(VaDAS-cog)比较2组患者治疗前后的认知功能障碍的改善情况;采用日常生活能力量表(ADLS)及Barthel指数评定量表(BI)评价并比较2组患者治疗前后的日常生活质量;采用改良的长谷川痴呆量表(HDS)评价并比较2组患者治疗前后的临床疗效,同时比较2组患者治疗期间的不良反应发生情况。结果治疗组患者治疗后认知功能的改善情况显著优于对照组(均P<0.05);治疗组治疗后的日常生活能力的ADLS评分和BI评分结果与对照组治疗后相比有显著差异(均P<0.05);治疗组临床疗效的总有效率显著高于于对照组(90.48%vs73.17%,χ2=4.196,P=0.041);两组患者在治疗期间的不良反应发生率差异无统计学意义(P>0.05)。结论尼莫地平联合多感官刺激技术治疗VaD能够显著提高临床疗效,改善患者的认知状态,提高患者的生活质量,且安全性良好,适合临床上进一步推广应用。

Objective To study the clinical efficacy and quality-of-life scale of nimodipine combined with multisensory stimulation technique in the treatment of vascular dementia(VaD)Method Eighty-three cases of VaD were randomly divided into the control group(forty-one)and the treatment group(forty-two).The control group were treated with nimodipine on the basis of routine treatment,and the treatment group were treated with multisensory stimulation technique on the basis of the control group.MMSE and VaDAS-cog were used to compare the improvement of cognitive function before and after treatment in the two groups.The daily life quality of two groups was evaluated by the daily living ability scale(ADLS)and the Barthel index scale(BI)before and after treatment.The modified Kyohko Hasegawa's dementia scale(HDS)was used to evaluate and compare the clinical efficacy of the two groups before and after treatment.The adverse reactions of two groups were compared between the two groups.Results The improvement of cognitive function in the treatment group was significantly better than that in the control group(P<0.05).The ADLS scores and BI scores of the daily living ability after treatment in the treatment group were significantly different from those in the control group(P<0.05).The total efficiency of clinical efficacy in the treatment group was significantly better than the control group(90.48%vs 73.17%,χ2=4.196,P=0.041).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Nimodipine combined with multisensory stimulation technique in the treatment of VaD can significantly improve the clinical efficacy,improve the cognitive status of patients and improve their quality of life.This therapy is safe and suitable for clinical application.