托吡酯对癫痫患者血清NPY、BD-NF表达及临床效果分析

Topiramate on epilepsy serum NPY, BD-NF expression and clinical effect analysis

目的探讨托吡酯治疗癫痫患儿的临床效果及对血清神经肽Y(NPY)、脑源性神经营养因子(BD-NF)水平的影响。方法选取2013年1月至2016年1月在本院诊治的癫痫患儿100例,采用SPSS16.0软件生成随机数字分为托吡酯组和左乙拉西坦组各50例,两组均治疗3个月后进行疗效评价。结果治疗前,托吡酯组和左乙拉西坦组患儿的血清NPY、BD-NF水平差异无统计学意义(P>0.05);治疗3个月后,托吡酯组的NPY、BD-NF水平均低于左乙拉西坦组,差异均有统计学意义(P<0.05),托吡酯组总有效率84.00%(42/50),左乙拉西坦组总有效率66.00%(33/50),差异具有统计学意义(P<0.05);托吡酯组总有效率78.00%(39/50),左乙拉西坦组总有效率64.00%(32/50),差异具有统计学意义(P<0.05);治疗过程中,托吡酯组不良反应发生率12.00%(6/50),左乙拉西坦组不良反应发生率24.00%(12/50),2组比较差异无统计学意义(P>0.05)。结论托吡酯治疗癫痫患儿的临床效果优于左乙拉西坦,能更显著的降低患儿血清NPY。

Objective To investigate the clinical effect of topiramate in the treatment of children with epilepsy and serum neuropeptide Y(NPY),brain-derived neurotrophic factor(BD-NF)level of influence.Method From January 2013 to January 2016 in our hospital diagnosis and treatment of children with epilepsy in one hundred cases,using SPSS16.0 software to generate randomly divided into topiramate group and levetiracetam group with fifty cases in each group,and evaluate the efficacy of the two groups were treated for 3 months.Results Before treatment,there was no significant difference of serum NPY and BD-NF levels in the topiramate group and levetiracetam group(P>0.05);after 3 months of treatment,topiramate group of NPY,BD-NF were lower than those of levetiracetam group,the differences were statistically significant(P<0.05),topiramate group total effective rate was 84%(42/50),levetiracetam group,the total efficiency of 66%(33/50),the difference was statistically significant(P<0.05);topiramate group total effective rate was 78%(39/50),levetiracetam group,the total efficiency of 64%(32/50),the difference was statistically significant(P<0.05);the course of treatment,the rate of adverse reactions occurred in topiramate group 12%(6/50),left levetiracetam group the adverse reaction rate of 24%(12/50),the two groups had no statistically significant difference(P>0.05).Conclusion Topiramate in the treatment of children with epilepsy clinical effect is better than that of levetiracetam,can decrease the level of serum NPY and BD-NF.