慢性阻塞性肺疾病急性加重期合并2型糖尿病患者中超敏C反应蛋白及血浆纤维蛋白原变化的研究

Study of High Sensitive C Reactive Protein and Fibrinogen on Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Patients with Type 2 Diabetes

目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)合并2型糖尿病(T2DM)患者中超敏C反应蛋白(hs-CRP)及血浆纤维蛋白原(FIB)变化。方法选取2013年9月—2016年3月亳州市人民医院收治的AECOPD合并T2DM患者70例作为A组,同期在本院治疗的AECOPD患者70例作为B组,同期在本院体检健康人群70例作为C组。检测所有患者的hs-CRP和FIB水平,并进行组间比较。结果 A组的hs-CRP、FIB水平高于B、C组,B组的hs-CRP、FIB水平高于C组(P<0.05)。结论 AECOPD合并T2DM患者hs-CRP和FIB水平均高于单纯的AECOPD患者,提示其炎性反应有明显增加,应在临床诊治中给予关注。

Objective To investigate high sensitive c reactive protein(hs-CRP)and fibrinogen(FBI)on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)in patients with type 2 diabetes(T2DM).Methods AECOPD in patients with T2DM,pure AECOPD patients and healthy people,70 cases in each points into A,B,C three groups,in Haozhou People's Hospital,from September 2013 to March 2016,the inflammatory response in all patients to detect signs mark the content of FIB and hs CRP were compared between groups.Results Significantly higher of levels of hs-CRP and PBI in group A compared with the group B and group C(P<0.05).In addition,a significantly higher of levels of hs-CRP and PBI in group B compared with the group C(P<0.05).Conclusions The content of FIB and hs-CRP in patients with AECOPD combined with T2DM were significantly higher than those of patients with simple AECOPD,indicating that the inflammatory reaction was significantly increased,which should be given attention in clinical diagnosis and treatment.