活化T细胞核因子与肿瘤生物学行为的研究进展

Advances in research on nuclear factor of activated T cells with tumor biological behavior

NFAT蛋白的相关信号传导通路对于细胞功能的调节起到十分重要的作用,如对细胞的增殖、分化、侵袭、转移、血管形成和肿瘤微环境的调节,同时,其在胚胎发育、器官发生、免疫反应及炎症反应中均扮演着重要角色。虽然NFAT家族已被证明在肿瘤的发生发展中有重要的调节功能,但由于其家族中不同亚型在不同细胞中起的作用不同,故进一步了解NFAT家族在肿瘤演变过程中的作用机制。

The NFAT protein signaling pathway plays an important role in the regulation of cell function,such as cell proliferation,differentiation,invasion,metastasis,angiogenesis and tumor microenvironment,and it is also important in the development in embryogenesis,organogenesis,immune response and inflammatory response.Although the NFAT family has been shown to be a key role in the development of tumors,the different isoforms of the NFAT family play a different role in different cells,to understand the role and mechanism of the NFAT family in tumor development and progression will help to develop new strategies for targeting NFAT tumor therapy.