胸腺重建的研究进展

Research progress on thymus reconstruction

作为T细胞发育的主要器官,胸腺在产生强大的适应性免疫应答及应对来自病原体和肿瘤的威胁时发挥主要作用。随着对胸腺作用的深入了解,人们逐渐意识到胸腺对急性和慢性损伤均很敏感。胸腺在许多有害因素的作用下会迅速衰退,同时也会随着年龄的增长而衰退。胸腺恢复和重建能使其功能恢复至一定水平。胸腺上皮祖细胞过继免疫、输注IL-2及血管生长因子、调整c-Met信号通路等均可促进胸腺恢复及T细胞再生。

Thymus,a main organ for T cell development,plays a pivotal role in adaptive immune response and dealing with the threaten from pathogens and tumors.With the deep understanding of the thymus,people have been realizing that the thymus is extremely sensitive to acute and chronic injuries as well as involution with age.Thymus regeneration can recover its function to a certain level.Up to now,these methods including adoptive thymic epithelial progenitor cells immunotherapy,injection of IL-2 and angiogenesis factor and regulation of c-Met signal are able to promote thymus recovery and T cell regeneration.