海藻酸钠微球加固栓塞对肝癌介入治疗效果及血清学指标的影响

Effect of sodium alginate microsphere reinforced embolization on the efficacy and serological indexes of interventional therapy for liver cancer

目的探讨海藻酸钠微球加固栓塞对肝癌介入治疗效果及血清学指标的影响。方法回顾性分析2014年1月—2016年12月收治于我院接受介入治疗的原发性肝癌202例患者,根据所用栓塞材料不同分为两组,即对照组101例,采用碘化油+明胶海绵颗粒栓塞;观察组101例,采用海藻酸钠微球加固栓塞。比较两组患者治疗后临床疗效、肝功能水平、复发相关血清指标水平。结果动脉介入治疗1周后,观察组患者血清中VEGF、AFP、EC、MMP水平较对照组明显降低(P<0.05);接受动脉介入治疗后3个月,观察组患者CR、PR、RR、DCR均优于对照组(P<0.05);SD、PD较对照组降低(P<0.05);观察组患者肝功能指标ALT、AST、TBIL、DBIL水平改善优于对照组(P<0.05)。结论在原发性肝癌介入治疗中采用海藻酸钠微球加固栓塞治疗,改善肝功能,明显抑制肿瘤细胞转移,改善相关血清学指标。

Objective:To investigate the effect of alginate microspheres embolization with reinforcement effect and serological marker for hepatocellular carcinoma.Methods:Retrospective analysis of January 2014~2016 year in December in our hospital for interventional treatment of 202 cases of primary liver cancer patients,according to the different embolic materials were divided into two groups,namely the control group of 101 cases,using the lipiodol embolization;101 cases in the observation group using sodium alginate microspheres reinforced embolism.Clinical efficacy of two groups were compared after treatment,liver function,recurrence related serum indexes.Results:The coronary intervention after 1 weeks of treatment,the observation group VEGF in serum of patients with AFP.,EC,MMP levels were significantly lower than those in the control group(P<0.05);3 months after interventional therapy,the patients in the observation group were CR,PR,RR,DCR were better than the control group(P<0.05);SD,PD lower than the control group(P<0.05);the observation group of patients with liver function ALT,AST,TBIL,DBIL level is better than the control group(P<0.05).Conclusion:In interventional treatment of primary liver cancer by strengthening alginate microspheres embolization,improve liver function,inhibit tumor cell metastasis,improve related serological indicators.