树突状细胞在银屑病中的作用研究进展

Role of dendritic cells in psoriasis formation

银屑病是一种由于免疫系统异常活化导致的慢性皮肤炎症,其发病机制仍未完全阐明。树突状细胞、巨噬细胞、Th17细胞、γδT细胞、3型固有淋巴细胞等多种类型的免疫细胞在银屑病中发挥重要作用,而树突状细胞作为炎症和免疫应答的始动环节,在其中起到关键的调控作用。不同亚群的树突状细胞具有不同的功能,本文旨在总结树突状细胞及其不同的亚群在银屑病发生发展过程中发挥的作用及其机制的研究进展。

Psoriasis is a common,chronic autoimmune/inflammatory disease directed by abnormal activation of skin immune system.It is characterized by erythematous plaques and slivery scales in the patients′lesional sites.Dendritic cells,macrophages,gamma delta T cells and group 3 innate lymphocytes are great contributors to the progress of the disease,as they are the main source of proinflammatory cytokines like TNF-α,IL-1β,IL-6,IFN-α,IL-23 and IL-17.Particularly,as the initiator of the inflammation,DCs are indispensable of the progress.There are different subpopulations of dendritic cells in the skin,in this review,we are trying to elaborate their unique location and function based on the published articles.