婴儿猝死综合征研究现状

Research status of sudden infant death syndrome

婴儿猝死综合征(sudden infant death syndrome,SIDS)是婴儿死亡的重要原因。2013年HRS/EHRA/APHRS专家共识将不明原因的婴儿猝死纳入遗传性心律失常范围。约12%的SIDS由长QT综合征导致,与SIDS相关的离子通道病还包括Brugada综合征、儿茶酚胺敏感性多形性室速、短QT综合征。此外,研究发现早期复极常伴随长QT综合征、Brugada综合征、短QT综合征疾病出现,并且进一步增加心律失常事件的风险。心电图描记术简单、无创、廉价、易行,对遗传性心律失常诱发的SIDS有重要的筛查、预警和诊断意义。

Sudden infant death syndrome(SIDS)is an important cause of infant death.SIDS of unknown causes was incorporated into the scope of hereditary arrhythmia by HRS/EHRA/APHRS expert consensus in 2013.Long QT syndrome contributes to about 12%of SIDS,and other related ion channelopathies include Brugada syndrome,catecholaminergic polymorphic ventricular tachycardia and short QT syndrome.In addition,it is revealed that early repolarization is usually accompanied by long QT syndrome,Brugada syndrome and short QT syndrome,and further increases the risk of arrhythmia events.With its easiness,noninvasiveness,low-price and operability,electrocardiography plays an important role in screening,making early warning and diagnosing SIDS induced by hereditary arrhythmia.