高尿酸人群平板运动试验中心脏变时功能改变

Changes of cardiac chronotropic function among hyperuricemic population during treadmill exercise test

目的研究高尿酸人群在平板运动试验中心脏变时功能的变化。方法将受试人群分为对照组127例、高尿酸组121例,观察对比两组人群在运动试验过程中达到运动峰值时间,心脏变时指数(CRI),休息2 min后心率、收缩期血压下降百分比,心率、血压恢复至运动前水平的时间等指标。结果高尿酸组运动峰值时间较对照组提前,且心脏变时功能不良,休息2 min后心率、收缩期血压下降百分比较对照组低,心率及血压恢复至运动前水平时间比对照组长,两组比较差异均有统计学意义。结论高尿酸人群易出现心脏变时功能不良,提示其心脏自主神经功能容易受损,心血管事件的危险性增加,预后不良,临床上要给予足够的重视。

Objective To investigate the changes of cardiac chronotropic function in hyperuricemic patients during treadmill exercise test(TET).Methods The research objects were divided into control group(127 cases)and hyperuricemia group(121 cases).The peak exercise time,chronotropic response index(CRI),recovery percentage of heart rate and systolic blood pressure(SBP)two minutes after rest,recovery time of heart rate and blood pressure back to pre-exercise level,and other indexes were observed and compared between the two groups during TET.Results In hyperuricemia group,the peak exercise time came earlier and cardiac chronotropic function was worse than that in the control group;the recovery percentage of heart rate and SBP two minutes after rest decreased if compared with the control group;the recovery time of heart rate and blood pressure back to pre-exercise level was longer than that in the control group,all with statistically significant differences.Conclusion Hyperuricemic people are prone to cardiac chronotropic dysfunction,which suggests the fragility of cardiac autonomic nerve function,increased risk of cardiovascular events and poor prognosis.Therefore,enough attention should be paid on these patients clinically.