非小细胞肺癌组织中Hsp90β和survivin的表达及其临床意义

Expression of Hsp90β and survivin in non-small cell lung cancer and and their clinical significance

目的探讨Hsp90β和survivin在非小细胞肺癌(NSCLC)组织中的表达特征及其临床意义。方法免疫组织化学法检测80例NSCLC组织、66例癌旁组织及34例正常肺组织中Hsp90β和survivin的表达,并分析两者表达的相关性及其与NSCLC临床病理特征之间的关联性。结果 Hsp90β与survivin在NSCLC组织当中的表达高于癌旁肺组织和正常肺组织;特别是低分化、淋巴结转移及临床分期较晚患者的肺癌组织当中二者表达明显增高;并且Hsp90β与survivin在NSCLC组织中的表达呈正相关。结论 Hsp90β和survivin在NSCLC组织中大部分呈现中或高表达,表明二者可能参与NSCLC的发生和发展。

Objective To investigate the expression and clinical significance of Hsp90βand survivin in non-small cell lung cancer(NSCLC).Methods The expression level of Hsp90βand survivin was detected by IHC respectively in 80 NSCLC,66 adjacent normal lung tissues and 34 normal lung tissues.The correlation between them and their association with the clinicopathological features of NSCLC were analyzed.Results The expression of Hsp90βand survivin was obviously higher in NSCLC tissues than adjacent normal lung tissues and normal lung tissues,and the up-regulated expressions of Hsp90 and survivin were correlated with poorly differentiation,lymph node metastasis and advanced clinical stages of NSCLC.Moreover,the expression of Hsp90βwas positively related with the expression of survivin.Conclusion Hsp90βand surviving are highly expressed in NSCLC,which indicate that they may be involved in the occurrence and development of NSCLC.