血清NSE、BNP和D-二聚体水平在预测慢阻肺急性加重中的临床意义

Clinical significance of serum NSE,BNP and D-dimer levels in prediction of acute exacerbation of COPD

目的研究慢性阻塞性肺疾病急性期(AECOPD)患者血清神经元特异性烯醇化酶(NSE)血清脑钠肽(BNP)和D-二聚体的水平及其临床意义。方法选取AECOPD患者87例、慢性阻塞性肺疾病稳定期87例、健康对照者50例,分别测定慢性阻塞性肺疾病患者急性加重期,稳定期及健康对照者血清NSE、BNP和D-二聚体水平。结果 AECOPD患者血清NSE、BNP和D-二聚体水平显著高于正常对照组(P<0.05);AECOPD患者血清中的NSE、BNP和D-二聚体水平显著高于慢性阻塞性肺疾病稳定期(P<0.05)。结论动态监测慢性阻塞性肺疾病患者血清NSE、BNP和D-二聚体水平对慢性阻塞性肺疾病的急性发作有较好的预测作用。

Objective To explore the clinical significance of NSE,BNP and D-dimer levels in predicting acute exacerbation of COPD(AECOPD).Methods 87 patients with AECOPD,87 patients with COPD and 50 healthy volunteers who met with the criteria were enrolled in this study.Their serum levels of NSE,BNP and D-dimer were determined by immunoradiometric assay,fluorescence immunoassay,and Turbidimetric inhibition immunoassay separately.Results The levels of NSE,BNP and D-dimer in the AECOPD group were significantly higher than those in the control group(P<0.05),and those in the stable COPD patients(P<0.05).Conclusion Dynamic monitoring of plasma NSE,BNP and D-dimer levels can predict the acute exacerbation of COPD.