婴幼儿支气管哮喘和支气管肺发育不良伴喘息患儿的肺功能比较

Comparison of pulmonary function in infants with asthma and bronchopulmonary dysplasia with wheezing

目的比较婴幼儿哮喘和支气管肺发育不良伴喘息(bronchopulmonary dysplasia with wheezing,BPDW)患儿潮气肺功能的差异。方法对29例BPDW患儿进行潮气呼吸肺功能测试,同时选取潮气肺功能阻塞程度与BPDW患儿一致的婴幼儿哮喘患儿33例,所有患儿均给予吸入布地奈德气雾剂100μg/次,2次/天,治疗3个月后,对两组患儿再次进行肺功能检测,评估两组患儿肺功能恢复情况。结果哮喘组和BPDW组患儿肺功能参数(MV、RR、VT/Kg、TI/TE、t PF%t E、VPF%VE)在治疗前比较差异无统计学意义(P>0.05);哮喘组患儿治疗前后肺功能参数比较,差异有统计学意义(P<0.05);BPDW组患儿在治疗前后肺功能参数比较,差异无统计学意义(P>0.05);哮喘组和BPDW组患儿在治疗后肺功能参数比较,差异有统计学意义(P<0.05)。结论与婴幼儿支气管哮喘相比,BPDW患儿的肺功能在治疗后恢复不明显,存在不可逆的气道受损;潮气呼吸肺功能在一定程度上可用来鉴别BPDW患儿。

Objective To compare the difference of pulmonary function between infants with asthma and bronchopulmonary dysplasia with wheezing(BPDW).Methods The pulmonary function test was performed on 29 children with BPDW,and 33 children with asthma were consistent with those with BPDW.All children were given 100μg of inhaled budesonide aerosol every time,2 times/day.3 months after treatment,their pulmonary function test was compared between the two groups.Results There was no significant difference in lung function parameters(MV,RR,VT/Kg,TI/TE,tPF%tE,VPF%VE)between the asthma group and the BPDW group before treatment(P>0.05).There were significant differences in lung function parameters among the asthma patients before and after treatment(P<0.05),there was no significant difference in pulmonary function parameters in the BPDW group before and after treatment(P>0.05),and the difference was statistically significant between the two groups after treatment(P<0.05).Conclusion Compared with asthma in infants and young children,BPDW children with lung function after treatment is not obviously improved,and there is irreversible airway damage.Tidal respiratory lung function can be used to identify children with early BPDW at certain extent.